Ⅰ型和Ⅱ型心肾综合征相关生物标志物研究进展

王孟孟; 乔冬雪; 高新; 杨波; 郭茂娟; 杨洪涛

doi:10.13422/j.cnki.syfjx.20191328

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Ⅰ型和Ⅱ型心肾综合征相关生物标志物研究进展

综述 | 更新时间：2021-02-09

- Ⅰ型和Ⅱ型心肾综合征相关生物标志物研究进展
- Type I and Ⅱ Cardiorenal Syndrome-related Biomarkers
- 中国实验方剂学杂志 2019年25卷第20期页码：222-228
- 作者机构：
  
  1.天津中医药大学　第一附属医院，天津　 300000；
  2.天津中医药大学，天津　 300000
- 作者简介：
  
  王孟孟，在读硕士，从事中医及中西医结合治疗肾脏病研究，E-mail：1711013392@qq.com
  杨波，博士，副主任医师，从事中医及中西医结合治疗肾脏病研究，E-mail：yb8203@126.com
- 基金信息：
  
  国家自然科学基金面上项目(81774065;81774071);国家自然科学基金青年基金项目(81303092)
- DOI：10.13422/j.cnki.syfjx.20191328
  中图分类号： R22; R242; R2-031; R285.5; R287
- 收稿日期：2018-10-16，
  
  网络出版日期：2019-03-20，
  
  纸质出版日期：2019-10-20
- 稿件说明：
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王孟孟, 乔冬雪, 高新, 等. Ⅰ型和Ⅱ型心肾综合征相关生物标志物研究进展[J]. 中国实验方剂学杂志, 2019,25(20):222-228.

Meng-meng WANG, Dong-xue QIAO, Xin GAO, et al. Type I and Ⅱ Cardiorenal Syndrome-related Biomarkers[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(20): 222-228.
王孟孟, 乔冬雪, 高新, 等. Ⅰ型和Ⅱ型心肾综合征相关生物标志物研究进展[J]. 中国实验方剂学杂志, 2019,25(20):222-228. DOI： 10.13422/j.cnki.syfjx.20191328.

Meng-meng WANG, Dong-xue QIAO, Xin GAO, et al. Type I and Ⅱ Cardiorenal Syndrome-related Biomarkers[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(20): 222-228. DOI： 10.13422/j.cnki.syfjx.20191328.

摘要

心脏和肾脏的生理病理相互依存，相互影响，其中任何一个器官的功能障碍导致另一个器官的功能障碍，即为心肾综合征，以Ⅰ型和Ⅱ型的发病率最高，临床最为常见。中医对心肾同病的认识历史悠久，认为本病的病位在心和肾，采用温阳益气，活血利水等方法治疗，有效改善了患者的心肾功能。然而，心肾综合征发生的病理机制复杂，且临床表现多样，导致对疾病早期的临床诊疗较为困难，从而错过最佳干预时机，使疾病预后不良。生物标志物在预测心肾综合征的发生、发展方面发挥着至关重要的作用，因此，寻找特异性和敏感性较好的生物标志物，准确评价心脏和肾脏生理病理的变化，以达到对心肾综合征的早期诊断、早期干预，提升疾病诊疗效果的目的。目前，国内外学者研究和应用较多的标志物主要集中于肾小管损伤，包括中性粒细胞明胶酶相关载脂蛋白、肾损伤因子-1，尿白细胞介素-18等。此外，还有一些其他研究成果，细胞周期阻滞诱导因子如胰岛素样生长因子结合蛋白7，金属蛋白酶组织抑制因子-2，以及与矿物质代谢相关的成纤维细胞生长因子23等。这些生物标志物在机体内含量升高的时间都早于血清肌酐升高的时间，能较好地预测早期心肾综合征的发生，有较高的应用价值和研究价值。通过对国内外文献中Ⅰ型和Ⅱ型心肾综合征的相关生物标志物进行总结，筛选出了几种具有代表性的标志物的研究进展进行综述，为相关研究提供参考。

Abstract

The physiology and pathology of the heart and kidney are interdependent and interact with each other

and dysfunction of any one of them causes dysfunction of the other

namely cardiorenal syndrome

in which type I and type Ⅱ have the highest incidence rate and are the commonest in clinic. Traditional Chinese medicine has a long history of treating the cardiorenal syndrome. It believes that the disease is located in the heart and kidney

and Wenyang Yiqi

Huoxue Lishui and other methods shall be adopted to effectively improve the heart and kidney function of patients. However

the pathogenesis of cardiorenal syndrome is complicated

and the clinical manifestations are diverse

which makes it difficult to diagnose and treat in the early stage

and causes missing of the best intervention timing and a poor prognosis. Biomarkers play a vital role in predicting the occurrence and development of cardiorenal syndrome. Therefore

efforts shall be made to look for biomarkers with better specificity and sensitivity

accurately evaluate physiological and pathological changes in heart and kidney

so as to achieve early diagnosis and early intervention of cardiorenal syndrome

and improve the effect of disease diagnosis and treatment. At present

domestic and foreign scholars have studied and applied more markers mainly in renal tubular injury

including neutrophil gelatinase-associated lipocalin

kidney injury molecule-1 and urinary interleukin-18. In addition

other studies have found cell cycle arrest inducing factors

such as insulin-like growth factor binding protein 7

tissue inhibitor metallo proteinase-2

and fibroblast growth factor 23 associated with mineral metabolism. The increase of the content of these biomarkers in the body is earlier than the rise of serum creatinine

which can better predict the occurrence of early cardiorenal syndrome

and has a high application value and research value. After summarization of the biomarkers relating to type I and Ⅱ cardiorenal syndrome in domestic and foreign literatures

the research progress of several representative markers were reviewed to provide reference for related research.

关键词

Keywords

references

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