Objective:

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To establish a mathematical model of total statistical moment

information amount and one-time steady-state feeding quantity of HPLC fingerprint of traditional Chinese medicines (TCMs) and their classical prescriptions

and to carry out experimental verification.

Method:

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The total statistical moment principle

Hardy-Weinberg equilibrium principle and one-time steady-state feeding quantity calculation method were used to study the total statistical moment parameters and one-time steady-state feeding quantity of 15 batches of original medicinal materials

decoction pieces and compound preparations of Taohong Siwutang

these original medicinal materials were from three producing areas.

Result:

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In addition to the total first-order moment

RSD of total zero-order moment

total second-order moment

information entropy and information amount of each medicinal material

decoction piece and compound were all greater than 10%. In the case of single original medicinal material

except for Angelicae Sinensis Radix (142.34 kg)

the one-time steady-state feeding quantity calculated according to the RSD change of the accumulated information amount of the whole prescription was the largest (59.10 kg)

and according to ratio of the whole prescription

one-time steady-state feeding quantity was the largest (958.57 kg). In the case of processed products

the one-time steady-state feeding quantity of the whole prescription was the largest (73.18 kg) except for Carthami Flos processed with wine (83.28 kg)

while according to the whole prescription

one-time steady-state feeding quantity of each processed products was the same as that of the original medicinal material. The one-time steady-state feeding quantity of the compound consisted of the original medicinal materials or processed products was often higher than that of the single medicinal material.

Conclusion:

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The components of TCM are controlled by genetic polymorphism

the chromatographic characteristics (types of components) of Chinese medicine is similar and the intensity of action (content of components) is different. The stability of total first-order moment and information entropy indicates that the overall chemical structure of TCM multi-component system has a stable imprinting trend. The one-time steady-state feeding quantities of each medicinal material in Taohong Siwutang and this compound are far greater than the prescription amount

which can provide reference for the industrial production.