轮状病毒与TLRs的关系及其中医药研究进展

周晓凤; 曹志群; 王晓妍; 孙蓉

doi:10.13422/j.cnki.syfjx.20191529

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轮状病毒与TLRs的关系及其中医药研究进展

综述 | 更新时间：2021-02-09

- 轮状病毒与TLRs的关系及其中医药研究进展
- Relationship Between Rotavirus and TLRs and Research Progress of Traditional Chinese Medicine
- 中国实验方剂学杂志 2019年25卷第17期页码：202-208
- 作者机构：
  
  1.山东中医药大学，济南　 250355；
  2.山东大学，济南　 250012
- 作者简介：
  
  周晓凤，在读博士，从事消化系统疾病的临床及实验研究，E-mail：1223603251@qq.com
  王晓妍，博士后，讲师，从事中药药理与毒理研究，E-mail：qingdai1982@126.com
- 基金信息：
  
  “泰山学者”建设工程专项(Ns201511107);国家自然科学基金青年基金项目(81704038);山东省博士后基金项目(201602030)
- DOI：10.13422/j.cnki.syfjx.20191529
  中图分类号： R22; R242; R2-031; R287; R285.5
- 收稿日期：2019-01-18，
  
  网络出版日期：2019-04-18，
  
  纸质出版日期：2019-09-05
- 稿件说明：
移动端阅览
周晓凤, 曹志群, 王晓妍, 等. 轮状病毒与TLRs的关系及其中医药研究进展[J]. 中国实验方剂学杂志, 2019,25(17):202-208.

Xiao-feng ZHOU, Zhi-qun CAO, Xiao-yan WANG, et al. Relationship Between Rotavirus and TLRs and Research Progress of Traditional Chinese Medicine[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(17): 202-208.
周晓凤, 曹志群, 王晓妍, 等. 轮状病毒与TLRs的关系及其中医药研究进展[J]. 中国实验方剂学杂志, 2019,25(17):202-208. DOI： 10.13422/j.cnki.syfjx.20191529.

Xiao-feng ZHOU, Zhi-qun CAO, Xiao-yan WANG, et al. Relationship Between Rotavirus and TLRs and Research Progress of Traditional Chinese Medicine[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(17): 202-208. DOI： 10.13422/j.cnki.syfjx.20191529.

摘要

轮状病毒(Rotavirus，RV)感染人体，主要定植于人类小肠上皮细胞，造成小肠上皮细胞损伤，诱发腹泻、发热等症状，是引发婴幼儿腹泻的最常见原因之一。Toll样受体(Toll-like receptors，TLRs)作为一类在宿主免疫系统中具有重要作用的模式识别受体，在病毒感染人体后宿主免疫过程中扮演着极其重要的角色。不同的病毒感染人体后，各类病原体通过TLRs启动宿主免疫应答反应，诱导各类细胞因子的释放，激发人体出现发热、咳嗽、腹泻等一系列炎症反应，进一步可能导致更严重的不良后果。研究发现，针对不同病原体研发的各种有效治疗药物抗炎、抗病毒的作用机制可能与干预TLRs信号通路的转导，调节机体免疫反应密切相关。大量研究表明，轮状病毒感染可通过影响Toll样受体3(Toll-like receptor 3，TLR3)，Toll样受体4(Toll-like receptor 4，TLR4)信号转导通路上相关蛋白、基因的表达，刺激炎性细胞因子释放，诱导炎症反应，而导致发病。部分研究也从TLRs着手研究药物治疗轮状病毒性腹泻的作用机制，但是中医药与轮状病毒性腹泻的相关临床及实验研究较少涉及TLRs信号通路。因此，该文将从病毒感染与TLRs信号通路，RV感染与TLRs信号通路，轮状病毒性腹泻的相关中医药研究三方面阐述TLRs信号通路与不同病毒感染，尤其是与轮状病毒感染的关系，并对中医药治疗轮状病毒性腹泻相关实验研究进行综述，以期指导基于TLR3，TLR4信号通路的中医药治疗轮状病毒性腹泻的相关临床及实验研究。

Abstract

Rotavirus (RV) infection of human body is mainly colonized in human intestinal epithelial cells

which results in small intestinal epithelial cell damage

and then induces diarrhea

fever and other symptoms. It is one of the most common causes of infantile diarrhea. Toll-like receptors (TLRs)

as a kind of pattern recognition receptors

play an important role in the host immune system after virus infection. After different viruses infect human body

various pathogens trigger the host immune response through TLRs

induce the release of various cytokines

and stimulate a series of inflammatory reactions

such as fever

cough and diarrhea

which may further lead to more serious adverse consequences. According to the findings

the anti-inflammatory and anti-viral mechanisms of various effective drugs developed for different pathogens may be closely related to the intervention of TLRs signaling pathway and the regulation of immune response. A large number of studies have shown that rotavirus infection can induce inflammation by affecting the expressions of related proteins and genes in Toll-like receptor 3 (TLR3) and Toll-like receptor 4 (TLR4) signal transduction pathways

stimulating the release of inflammatory cytokines and inducing inflammatory response. Some studies on the mechanism of drug treatment for rotavirus diarrhea also started with TLRs

but only a few clinical and experimental studies on traditional Chinese medicine(TCM) and rotavirus diarrhea involve TLRs signaling pathway. Therefore

this article will focus on the relationship between TLRs signaling pathway and different viral infections

especially with rotavirus infection

in three aspects: viral infection and TLRs signaling pathway

RV infection and TLRs signaling pathway

and the research of traditional Chinese medicine in the treatment of rotavirus diarrhea

in order to guide the clinical and experimental studies on the treatment of rotavirus diarrhea with TCM based on TLR3 and TLR4 signaling pathways.

关键词

Keywords

references

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