Objective:

2

To discuss the clinical efficacy of modified Da Chengqitang by enema in treatment of postoperative inflammatory intestinal obstruction (EPISBO) after the operation and its effect on inflammatory factors

gastrointestinal motility and intestinal barrier function.

Method:

2

One hundred and six patients were randomly divided into control group (52 cases) and observation group (54 cases) by random number table. Patients in both groups were given fasting for solids and liquids

gastrointestinal decompression

maintaining water and electrolyte balance

nutritional support and other basic therapies. Patients in control group were given somatostatin for injection for continuous micro-pumping

0.003 5 mg·h

-1

·kg

-1

dexamethasone acetate tablets

2.5-5 mg/time

2 time/days. Patients with concurrent infection got ceftazidime for injection

30-100 mg·kg

-1

2-3 intravenous drips. In addition to the therapy of control group

patients in observation group were also given modified Da Chengqitang

125 mL/time

2 times/days. A course of treatment was 5 days. Time of remission of abdominal distention

recovery of exhaust gas

bowel sounds and diet

defecation

hospitalization and transitional surgery were recorded. And main gastrointestinal symptoms and signs were scored. And levels of serum interleukin-6 (IL-6)

tumor necrosis factor-

α

(TNF-

α

)

high-sensitivity C-reactive protein (hs-CRP)

vasoactive intestinal peptide (VIP)

gastrin

motilin

diamine oxidase and

D

lactic acid were detected.

Result:

2

After treatment

according to rank sum test analysis

the clinical efficacy in observation group was better than that in control group (

P

<

0.05). And indicators of gastrointestinal function (abdominal distension relief time

bowel sounds recovery time

recovery of exhaust

defecation time and diet recovery time) were all shorter than those in control group (

P

<

0.05

P

<

0.01). And average length of stay in observation group was shorter than that in control group (

P

<

0.01). According to exact probability analysis

there was no statistical difference in conversion rate between the two groups. And levels of IL-6

TNF-

α

hs-CRP

VIP

DAO

D

-lactic acid and scores of main gastrointestinal symptoms and signs were all lower than those in control group (

P

<

0.01)

while levels of motilin and gastrin were higher than those in control group (

P

<

0.01).

Conclusion:

2

In addition of routine therapy of western medicine

modified Dachengqi Tang had effects in resisting inflammation

regulating gastrointestinal hormones

and protecting intestinal barrier function

so can improve gastrointestinal motility

alleviate symptoms

shorten the course of disease and improve the clinical efficacy.