Objective:

2

To observe the efficacy of modified Fangji Huangqitang on early renal damage in hypertension (Qi deficiency and dampness obstruction syndrome) and its effect in resisting inflammation and protecting vascular endothelium.

Method:

2

One hundred and forty-four patients were randomly divided into control group and observation group by random number table. Patients in control group got losartan potassium tablets

50 mg/time

1 time/day

and nifedipine controlled-release tablets

30 mg/time

1 time/day. In addition to the therapy of control group

patients in observation group were alsog given modified Fangji Huangqitang

1 dose/day. The qualification rate of blood pressure was recorded for every week

and ambulatory blood pressure was detected before and after treatment. Standard deviation of systolic blood pressure for 24 h (24 hSSD)

standard deviation of diastolic pressure for 24 h (24 hDSD)

mean systolic blood pressure for 24 h (24 hSBP)

average diastolic pressure for 24 h (24 hDBP) were recorded

and dynamic pulse pressure index (PPI)

dynamic arteriosclerosis index (AASI)

and ratio of UmALB and creatinine (CR) were calculated

levels of beta 2 microglobulin (

β

2

-MG)

urinary

N

-acetyl-beta-glucosaminidase (NAG)

serum cystatin C (CysC)

urinary microalbumin (UmALB)

interleukin-6 (IL-6)

interleukin-1

β

(IL-1

β

)

tumor necrosis factor-

α

(TNF-

α

)

nitric oxide (NO)

endothelin-1 (ET-1) were detected

and symptoms and signs were scored.

Result:

2

During the 12-week observation period

the qualification rate of blood pressure in observation group was 89.09%

which was higher than 81.52%in control group (

χ

2

=18.776

P

<

0.01). Levels of 24 hSBP

24 hDBP

24 hSSD

24 h DSD

PPI

AASI

β

2

-MG

CysC

NAG

UmALB

UACR

IL-6

IL-1

β

TNF-

α

and ET-1 were lower than those in control group (

P

<

0.01)

while level of NO was higher than that in control group (

P

<

0.01). And by rank sum test

the clinical efficacy in observation group was better than that in control group (

Z

=2.146

P

<

0.05).

Conclusion:

2

In addition of the western medicine therapy

modified Fangji Huangqitang can be added to control blood pressure level

improve blood pressure compliance rate

reduce blood pressure variability

protect renal function

prevent and relieve clinical symptoms

improve the clinical efficacy

inhibit inflammatory reaction and improve endothelial function.