Objective:

2

To observe the clinical efficacy of modified Qingjin Huatan Tang on bronchiectasis with syndrome of phlegm-heat accumulating lung at acute exacerbation and its inhibitory effect on pro-inflammatory factors and proteolytic activity.

Method:

2

One hundred and thirty patients were randomly divided into control group and observation group by random number table. Patients in control group got tazobactam sodium and piperacillin sodium for injection

3.375 g/time

1 time/6 hours

and the types of antibiotics were regulated according to the bacterial culture results. And patients in control group also got Ambroxol Hydrochloride injection

30 mg/time

2 time/days

and postural drainage. In addition to the therapy of control group

patients in observation group were also given modified Qingjin Huatan Tang

1 dose/day. Before and after treatment

symptoms and signs were scored. And levels of white blood cell count (WBC)

neutrophile granulocyte (GRAN)

C-reactive protein (CRP)

procalcitonin (PCT) were detected. And scores of forced expiratory volume in one second (FEV

1

)

forced vital capacity (FVC)

peak expiratory flow rate (PEFR) and BODE were graded. And levels of tumor necrosis factor-

α

(TNF-

α

)

interleukin-4 (IL-4)

IL-6 and IL-8 in sputum

peripheral neutrophil elastase (NE) and cathepsin G were detected.

Result:

2

By rank sum test

the clinical efficacy in observation group was better than that in control group (Z=2.086

P

<

0.05)

while scores of symptoms and signs in observation group were lower than those in control group (

P

<

0.01). WBC

GRAN

CRP

PCT

airflow limitation (O)

dyspnea (D)

motor ability (E) score

BODE index

TNF-

α

IL-4

IL-6

IL-8

plasma NE and cathepsin G were all lower than those in control group (

P

<

0.01). And levels of FEV

1

FVC

PEF and FEV

1

/FVC were higher than those in control group (

P

<

0.01).

Conclusion:

2

In addition to routine anti-infection and expectoration western medicine therapy

modified Qingjin Huatan Tang can be added to control symptoms and signs

alleviate the degree of illness

improve pulmonary function and the quality of life of patients

and inhibit expression of airway pro-inflammatory factor and proteolysis

with a better clinical efficacy than pure western medicine.