Objective:

2

To observe the effect of Shenqi compound recipe on glucose and lipid metabolism in patients with Qi and Yin deficiency and blood stasis syndrome newly diagnosed type 2 diabetes mellitus (T2DM)

and its intervention effect on intestinal microecology and serum proinflammatory factors.

Method:

2

The 106 eligible patients were divided into the observation group (54 cases) and the control group (52 cases) by random number table method. Another 40 healthy volunteers in physical examination center of the hospital during the same period were enrolled as health control group. On the basis of

Guidelines for the Prevention and Treatment of Type

2

Diabetes in China

(2013

edition

)

control group was provided lifestyle interventions

such as reasonable diet

weight control

moderate exercise

salt restriction

tobacco control

alcohol restriction and psychological balance. In addition to the therapy of the control group

the observation group was given Shengi compound for oral administration

2 times/days. Both groups were treated for 8 weeks. The fasting blood glucose (FBG)

postprandial 2 h blood glucose (PBG)

glycosylated hemoglobin (HbA1c)

homeostasis model assessment-insulin resistance index (HOMA-IR)

total cholesterol (TC)

triglyceride (TG)

high-density lipoprotein cholesterol (HDL-C)

and low-density lipoprotein cholesterol (LDL-C) before and after treatment were evaluated. The structure and quantity of intestinal flora before and after treatment were detected. The traditional Chinese medicine(TCM)symptom was scored. The levels of interleukin-1

β

(IL-1

β

)

interleukin-6 (IL-6)

IL-8

and tumor necrosis factor-

α

(TNF-

α

) were measured before and after treatment.

Result:

2

FBG

PBG

HbA1c and HOMA-IR levels in observation group were lower than those in control group (

P

<

0.05). The operational taxonomy unit (OUT) of observation group was higher than that of control group (

P

<

0.05). The abundances of Bacteroides and Klebsiella in observation group were higher than those in control group

while actinomyces abundance was significantly lower than that in control group (

P

<

0.05). TC

TG and LDL-C levels in observation group were lower than those in control group

while HDL-C was higher than that in control group (

P

<

0.05). IL-1

β

IL-6

IL-8 and TNF-

α

levels in observation group were lower than those in control group (

P

<

0.01). Rank-sum test showed that the efficacy on diseases of observation group was better than that of control group after treatment (

Z

=2.134

P

<

0.05).

Conclusion:

2

Shenqi compound can regulate blood glucose and blood lipid in patients with newly diagnosed T2DM (Qi and Yin deficiency and blood stasis syndrome)

improve IR

intestinal microecology imbalance

and reduce non-specific inflammatory response

with a good clinical efficacy on intestinal microecology of patients with Qi and Yin deficiency and blood stasis syndrome newly diagnosed type 2 diabetes mellitus.