中医药干预溃疡性结肠炎Th17/Treg平衡的研究进展

吴东升; 曹晖; 张彧; 胡启华; 邹博

doi:10.13422/j.cnki.syfjx.20191637

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中医药干预溃疡性结肠炎Th17/Treg平衡的研究进展

综述 | 更新时间：2021-02-09

- 中医药干预溃疡性结肠炎Th17/Treg平衡的研究进展
- Advances in Research on Intervention of Th17/Treg Balance in Ulcerative Colitis by Traditional Chinese Medicine
- 中国实验方剂学杂志 2019年25卷第16期页码：213-219
- 作者机构：
  
  1.湖南中医药大学，长沙　 410208；
  2.湖南中医药大学　第一附属医院，长沙　 410007
- 作者简介：
  
  吴东升，在读硕士，从事肠道慢性疾病合并肛周病变的中医药治疗研究，E-mail：987909401@qq.com
  曹晖，副教授，硕士生导师，从事肠道慢性疾病合并肛周病变的防治研究，E-mail：caohui001818@sina.com
- 基金信息：
  
  国家自然科学基金项目(81603634);湖南省中医药科研计划重点项目(201804);湖南省卫生计生科研计划项目(C20180627)
- DOI：10.13422/j.cnki.syfjx.20191637
  中图分类号： R2-0; R289; R285.5
- 收稿日期：2019-01-30，
  
  网络出版日期：2019-05-06，
  
  纸质出版日期：2019-08-20
- 稿件说明：
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吴东升, 曹晖, 张彧, 等. 中医药干预溃疡性结肠炎Th17/Treg平衡的研究进展[J]. 中国实验方剂学杂志, 2019,25(16):213-219.

Dong-sheng WU, Hui CAO, Yu ZHANG, et al. Advances in Research on Intervention of Th17/Treg Balance in Ulcerative Colitis by Traditional Chinese Medicine[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(16): 213-219.
吴东升, 曹晖, 张彧, 等. 中医药干预溃疡性结肠炎Th17/Treg平衡的研究进展[J]. 中国实验方剂学杂志, 2019,25(16):213-219. DOI： 10.13422/j.cnki.syfjx.20191637.

Dong-sheng WU, Hui CAO, Yu ZHANG, et al. Advances in Research on Intervention of Th17/Treg Balance in Ulcerative Colitis by Traditional Chinese Medicine[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(16): 213-219. DOI： 10.13422/j.cnki.syfjx.20191637.

摘要

溃疡性结肠炎(UC)是一种常见的慢性非特异性的肠道炎症，其病程长且难以治愈，发病率逐年上升。辅助性T细胞17(Th17)是免疫促进细胞之一，而调节性T细胞(Treg)是一种免疫抑制细胞，Th17和Treg细胞共同维持着机体免疫微环境的平衡。在UC进展期间，引起炎症的Th17群体通常增加，而抑制Th17活性的Treg减少。其中，Th17介导免疫应答反应，Treg介导免疫抑制，两者协调平衡在溃疡性结肠炎的炎症和免疫过程中起关键作用。UC的西医治疗虽具有一定的效果，然而，副作用的频率和严重程度，不方便的剂量调节，以及部分价格过高限制了他们的临床应用。中药作为我国的传统医药，具有多靶点、多环节、多途径的治疗特点，在抗溃疡性结肠炎方面具有独特优势和广阔前景。近年来，中医药领域以Th17/Treg平衡为切入点，开展了大量中医药干预UC中Th17/Treg平衡的临床和实验研究，并取得了一定的成果，临床和实验证据明确表明干预Th17/Treg是中医药治疗溃疡性结肠炎的重要作用机制。本文主要对前人关于中药单体、组分或有效成分、中药复方对UC中Th17/Treg平衡的干预作用研究进行了总结与分析，有利于人们更为准确、全面地认识中医药干预UC中Th17/Treg平衡的作用机制，为临床合理设计抗溃疡性结肠炎治疗方案提供参考。

Abstract

Ulcerative colitis (UC) is a common chronic non-specific intestinal inflammation

which has a long course and is difficult to cure

and the incidence is increasing year by year. Helper T cells 17 (Th17) are one of immune-promoting cells

while regulatory sputum cells (Treg) are immunosuppressive cells

and Th17 cells and regulatory T cells together maintain the balance of the body's immune microenvironment. During progression of UC

the population of sputum helper cells 17 (Th17 cells) that cause inflammation generally increases

while the number of sputum regulatory T cells that inhibit Th17 cell activity decreases. Among them

Th17 cells mediate immune response

regulatory T cell-mediated immunosuppression

and the balance between the two plays a key role in the inflammation and immune process of ulcerative colitis. Although Western medicine treatment of UC has certain effects

however

The frequency and severity of side effects

inconvenient dose adjustments

and partial price excessions limit their clinical application.As a traditional medicine in China

traditional Chinese medicine(TCM) has multi-target

multi-link and multi-channel treatment characteristics

and has unique advantages and broad prospects in anti-ulcerative colitis. In recent years

the TCM field has taken Th17/Treg balance as the entry point

and carried out a large number of clinical and experimental studies on the intervention of TCM in Th17/Treg balance in UC

and achieved certain results. Clinical and experimental evidence clearly indicates intervention in Th17/Treg. It is an important mechanism of action of TCM in the treatment of ulcerative colitis. This paper mainly summarizes and analyzes the intervention effects of TCM monomer

component or active ingredient and TCM compound on Th17/Treg balance in UC

which is helpful for people to understand Chinese medicine intervention in UC more accurately and comprehensively. The mechanism of action of Th17/Treg balance provides a reference for the clinical design of a treatment plan for anti-ulcerative colitis.

关键词

Keywords

references

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