Objective:

2

To observe the clinical efficacy of addition and subtraction therapy of Taohong Siwutang combined with Chaihu Shugansan to unstable angina pectoris with type A behavior pattern (Qi stagnation and blood stasis syndrome)

and investigate its effects on proinflammatory factors and serotonin (5-HT).

Method:

2

One hundred twenty-four patients were randomly divided into control group (60 cases) and observation group(64 cases) by random number table. Patients in control group got Aspirin enteric-coated tablets

100 mg/time

1 time/day. Tigrillo tablets

90 mg/time

2 times/days. Metoprolol tartrate tablets

50 mg/time

2 times/days. Simvastatin tablets

10 mg/time

1 time/day. Nitroglycerin tablets

0.5 mg/time. Based on the treatment in control group

patients in observation group also received addition and subtraction therapy of Taohong Siwutang combined with Chaihu Shugansan

1 dose/day. The treatment course was 8 weeks in both groups. Number of attacks

duration

degree of pain and usage of nitroglycerin were recorded for every week. Before and after treatment

electrocardiogram was also recorded. And levels of triglyceride (TG)

total cholesterol (TC)

high density lipoprotein cholesterol (HDL-C)

low density lipoprotein cholesterol (LDL-C)

interleukin-6 (IL-6)

tumor necrosis factor-

α

(TNF-

α

)

hypersensitive C-reactive protein and 5-HT were detected. In addition

scores of Seattle Angina Scale (SAQ) and Qi stagnation and blood stasis syndrome were graded.

Result:

2

In the rank sum test

the curative effect in electrocardiogram of observation group was better than that of control group (

Z

=1.965

P

<

0.05). Number of attacks

duration

degree of pain and usage of nitroglycerin were all less than those in control group (

P

<

0.01). Scores of various dimensions in SAQ and the total scores of SAQ were all higher than those in control group (

P

<

0.01). Scores of various symptoms for Qi stagnation and blood stasis syndrome and the total scores were lower than those in control group (

P

<

0.01). Levels of LDL-C

IL-6

hs-CRP

TNF-

α

and 5-HT in observation group were lower than those in control group (

P

<

0.01)

while level of HDL-C was higher than that in control group (

P

<

0.01).

Conclusion:

2

On the basis of conventional western medicine

addition and subtraction therapy of Taohong Siwutang combined with Chaihu Shugansan can further control angina attack

relieve clinical symptoms

improve quality of life

regulate lipid metabolism

and can inhibit expression of proinflammatory factors and 5-HT

so it can play a role in stabilizing the disease.