Objective:

2

To discussed the clinical efficacy of addition and subtraction therapy of Shenling Baizhu San to antibiotic-associated diarrhea (AAD) with spleen-stomach deficiency and cold syndrome

and to investigate its effects on immune function and intestinal flora.

Method:

2

One hundred and fifteen patients were randomly divided into control group (57 cases) and observation group (58 cases) by random number table. Patients in control group got Shuangqi Ganjun Sanlian Huojun San

2 bags/time

2 times/days. Mengtuoshi San

1 bag/time

3 times/days

and they also got measures to prevent disturbance of water

electrolyte

acid-base balance and nutritional support. Based on the treatment in control group

patients in observation group also got addition and subtraction therapy of Shenling Baizhu San

1 dose/day. The course of treatment was 7 days in both groups. Before and after treatment

scores of symptoms

intestinal secretory immunoglobulin (SIgA) levels

peripheral blood immunoglobulin A (IgA)

G (IgG)

M (IgM) and T lymphocyte subsets (CD3

+

CD4

+

CD8

+

and CD4

+

/CD8

+

). Detection of bacillus faccalis in feces before and after treatment and the bacteria were cultured to identify and count bifidobacterium

lactobacillus and enterococcus. In addition

diamine oxidase (DAO) and D-lactic acid levels were detected before and after treatment.

Result:

2

In rank sum test

clinical efficacy in observation group was better than that in control group (

Z

=2.268

P

<

0.01). Scores of main symptoms

secondary symptoms

spleen-stomach deficiency and cold syndrome were lower than those in control group(

P

<

0.01). Levels of SIgA

IgA and IgG were significantly higher than those in the control group (

P

<

0.01). Levels of CD3

+

CD4

+

and CD4

+

/CD8

+

were higher than those in control group (

P

<

0.05)

while level of CD8

+

was lower than that in control group (

P

<

0.05). Bacillus in faeces was significantly lower than that in control group(

P

<

0.01). Count of enterococcus was lower than that in control group (

P

<

0.05)

while counts of bifidobacterium and lactobacillus were higher than those in control group (

P

<

0.05). In addition

levels of DAO and

D

-lactic acid were significantly lower than those in control group (

P

<

0.01).

Conclusion:

2

Based on conventional treatment

addition and subtraction therapy of Shenling Baizhu San can alleviate symptoms

improve clinical efficacy

improve immune function

regulate intestinal flora and promote the repair of intestinal mucosal barrier in the treatment of antibiotic-associated diarrhea (AAD) with spleen-stomach deficiency and cold syndrome.