丹酚酸B抗氧化应激损伤机制的研究进展

安丽平; 于琨; 耿海波; 王伟

doi:10.13422/j.cnki.syfjx.20192005

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丹酚酸B抗氧化应激损伤机制的研究进展

综述 | 更新时间：2021-02-09

- 丹酚酸B抗氧化应激损伤机制的研究进展
- Advances in Research on Mechanism of Salvianolic Acid B Against Oxidative Stress
- 中国实验方剂学杂志 2019年25卷第22期页码：227-234
- 作者机构：
  
  1.河北中医学院　基础医学院，河北省心脑血管病中医药防治研究重点实验室，石家庄　 050200；
  2.石家庄职业技术学院　食品与药品工程系，石家庄　 050081
- 作者简介：
  
  安丽平，硕士，讲师，从事心血管病的医药防治，Tel：0311-89926235，E-mail：anan08@126.com
  王伟，硕士，讲师，从事心血管病的医药防治，Tel：0311-89926235，E-mail：weiweiw1975@126.com
- 基金信息：
  
  河北省卫生厅科研基金项目(ZL20140249);河北省教育厅青年基金项目(QN2016137);河北省中医药管理局科研计划项目(2016003);河北中医学院青年科研基金项目(QNZ2014030;QNZ2014034)
- DOI：10.13422/j.cnki.syfjx.20192005
  中图分类号： R2-0; R22; R285.5; R284
- 收稿日期：2019-03-15，
  
  网络出版日期：2019-07-04，
  
  纸质出版日期：2019-11-20
- 稿件说明：
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安丽平, 于琨, 耿海波, 等. 丹酚酸B抗氧化应激损伤机制的研究进展[J]. 中国实验方剂学杂志, 2019,25(22):227-234.

Li-ping AN, Kun YU, Hai-bo GENG, et al. Advances in Research on Mechanism of Salvianolic Acid B Against Oxidative Stress[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(22): 227-234.
安丽平, 于琨, 耿海波, 等. 丹酚酸B抗氧化应激损伤机制的研究进展[J]. 中国实验方剂学杂志, 2019,25(22):227-234. DOI： 10.13422/j.cnki.syfjx.20192005.

Li-ping AN, Kun YU, Hai-bo GENG, et al. Advances in Research on Mechanism of Salvianolic Acid B Against Oxidative Stress[J]. Chinese journal of experimental traditional medical formulae, 2019, 25(22): 227-234. DOI： 10.13422/j.cnki.syfjx.20192005.

摘要

丹参始载于《神农本草经》，丹参具有活血祛瘀、凉血消痈的功效，近代药理学研究发现丹参具有强心、改善微循环、抗血栓等作用。临床当中常用丹参的水煎剂，丹参的水煎剂的溶解成分主要为丹酚酸类物质，其中丹酚酸类物质当中的丹酚酸B是丹参水溶性成分之一，具有很强的生理学活性，丹酚酸B是丹酚酸类物质当中抗氧化作用最强的。丹酚酸B在体内具有调节烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶，脱偶联型内皮一氧化氮合酶(eNOS)，并通过调节Janus蛋白酪氨酸激酶2/信号转导子和转录激活子3/血管内皮生长因子(JAK2/STAT3/VEGF)和肿瘤阻抑蛋白(p53)，B细胞淋巴瘤-2(Bcl-2)，Bcl-2相关X蛋白(Bax)，半胱氨酸的天冬氨酸蛋白水解酶-3(Caspase-3)抗凋亡通路，抑制细胞外信号调节激酶/有丝分裂原活化蛋白激酶(ERK/MAPK)，c-Jun氨基末端激酶/有丝分裂原活化蛋白激酶(JNK/MAPK)，丝裂原活化蛋白激酶p38(p38 MAPK)和雌激素受体

/磷脂酰肌醇3-激酶/丝氨酸-苏氨酸蛋白激酶/核转录因子-

B(ER

/PI3K/Akt/NF-

B)抗炎通路，沉默信息调节因子2相关酶1/核因子E2相关因子2/Kelch样ECH联合蛋白1-抗氧化反应元件(SIRT1/Nrf2/Keap1-ARE)和NAD依赖性脱乙酰酶sirtuin-3/

细胞上的叉头转录因子1/超氧化物歧化酶(SIRT3/FOXO1/SOD2)抗氧化通路和促自噬通路抑制氧化应激，保护组织器官免受氧化损伤。本文从丹酚酸B抗氧化应激损伤的通路研究出发，综述近五年发表在国内外期刊的相关研究，为扩大丹酚酸B临床应用范围提供新的思路。

Abstract

Salvia miltiorrhiza Bge was first published in

Shennong Bencaojing

. Salviae Miltiorrhizae Radix et Rhizoma has the effect of promoting blood circulation

cooling blood and eliminating phlegm. Modern pharmacological studies have found that Salviae Miltiorrhizae Radix et Rhizoma has strong heart

improve microcirculation and antithrombotic effects. The decoction of Salviae Miltiorrhizae Radix et Rhizoma is commonly used in clinical practice. The dissolved component of Salviae Miltiorrhizae Radix et Rhizoma is mainly salvianolic acid. Among them

salvianolic acid B is one of the water-soluble components of Salviae Miltiorrhizae Radix et Rhizoma. It has strong physiology. Activity

salvianolic acid B is the strongest antioxidant activity of salvianolic acids. Salvianolic acid B regulates nicotinamide adenine dinucleotide phosphate (NADPH) oxidase

decoupled endothelial nitric oxide synthase (eNOS)

in vivo

and regulates Janus protein tyrosine kinase 2/signal transducer and transcriptional activation 3/vascular endothelial growth factor (JAK2/STAT3/VEGF) and tumor suppressor(p53)

B cell lymphoma-2(Bcl-2)

Bcl-2-related X protein (Bax)

Caspase-3 anti-apoptotic pathway

inhibition of extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK)

c-Jun

-terminal kinase/mitogen-activated protein kinase (JNK/MAPK)

mitogen-activated protein kinase p38 (p38MAPK) and estrogen receptor alpha/phosphatidylinositol 3-kinase/serine-threonine protein kinase/nuclear transcription factor kappa B (ER

/PI3K/Akt/NF-

B) anti-inflammatory pathway

silencing information regulator 2 related enzyme 1/nuclear factor E2 related factor 2/Kelch-like ECH combined protein 1-antioxidant response element (SIRT1/Nrf2/Keap1-ARE) and NAD-dependent deacetylase sirtuin Forkhead transcription factor 1/superoxide dismutase on-3/

cells (NAD-dependent deace tylase sirtuin-3

SIRT3/FOXO1/SOD2) antioxidant pathway and autophagy pathway inhibit oxidative stress and protect tissues and organs from oxidative damage. Based on the study of the pathway of salvianolic acid B against oxidative stress injury

this paper reviews the related research published in domestic and foreign journals in the past five years

and provides new ideas for expanding the clinical application range of salvianolic acid B.

关键词

Keywords

references

范雅雯，梁丽嫦，张天奉，等．复方丹参滴丸通过miR-200b调控VEGF/TGF-β1影响糖尿病心肌病大鼠心脏的作用机制 [J]．中国实验方剂学杂志， 2019 ， doi: 10.13422/j.cnki.syfjx.20191606 http://doi.org/10.13422/j.cnki.syfjx.20191606 ．

ZHAI J , TAO L , ZHANG Y , et al . Salvianolic acid B attenuates apoptosis of HUVEC cells treated with high glucose or high fat via Sirt1 activation [J]. Evid Based Complement Alternat Med , 2019 , 21 ( 9846325 ): 1 - 11 .

韩聪，姜月华，李伟．黄芪-丹参药对改善高血压肾损害的研究进展 [J]．中国实验方剂学杂志， 2019 ， 25 ( 12 )： 214 - 220 ．

Balligand J L , Feron O , Dessy C . eNOS activation by physical forces: from short-term regulation of contraction to chronic remodeling of cardiovascular tissues [J]. Physiol Rev , 2009 , 89 ( 2 ): 481 - 534 .

曾静，李丹丹，赵弘轶，等． eNOS解偶联对大脑中动脉栓塞后大鼠神经血管单元的作用及机制 [J]．中风与神经疾病杂志， 2017 ， 34 ( 6 )： 500 - 503 ．

REN Y , TAO S , ZHENG S , et al . Salvianolic acid B improves vascular endothelial function in diabetic rats with blood glucose fluctuations via suppression of endothelial cell apoptosis [J]. Eur J Pharmacol , 2016 , 791 : 308 - 315 .

霍魁媛，常宏，王勇，等．槲皮素保护H2O2诱导的H9C2心肌细胞氧化损伤的作用机制 [J]．中国实验方剂学杂志， 2016 ， 22 ( 15 )： 122 - 127 ．

陈波，陆燕蓉，陈又南，等．血管内皮衰老和氧化应激 [J]．生理科学进展， 2015 ， 46 ( 1 )： 23 - 27 ．

Panday A , Sahoo M K , Osorio D , et al . NADPH oxidases: an overview from structure to innate immunity-associated pathologies [J]. Cell Mol Immunol , 2015 , 12 ( 1 ): 5 - 23 .

Kim Y W , Byzova T V . Oxidative stress in angiogenesis and vascular disease [J]. Blood , 2014 , 123 ( 5 ): 625 - 631 .

Datla S R , Peshavariya H , Dusting G J , et al . Important role of Nox4 type NADPH oxidase in angiogenic responses in human microvascular endothelial cells in vitro [J]. Arterioscler Thromb Vasc Biol , 2007 , 27 ( 11 ): 2319 - 2324 .

YANG K , LUO Y , LU S , et al . Salvianolic acid B and ginsenoside re synergistically protect against ox-LDL-induced endothelial apoptosis through the antioxidative and antiinflammatory mechanisms [J]. Front Pharmacol , 2018 , doi: 10.3389/fphar.2018.00662 http://doi.org/10.3389/fphar.2018.00662 .

Platt S R . Angiogenesis and cerebral neoplasia [J]. Vet Comp Oncol , 2005 , 3 ( 3 ): 123 - 138 .

HOU Y C , Liou K T , Chern C M , et al . Preventive effect of silymarin in cerebral ischemia-reperfusion-induced brain injury in rats possibly through impairing NF-kappaB and STAT-1 activation [J]. Phytomedicine , 2010 , 17 ( 12 ): 963 - 973 .

WANG W , HU W . Salvianolic acid B recovers cognitive deficits and angiogenesis in a cerebral small vessel disease rat model via the STAT3/VEGF signaling pathway [J]. Mol Med Rep , 2018 , 17 ( 2 ): 3146 - 3151 .

陈雪，沈楠，安英，等．丹酚酸B对氧化应激损伤乳鼠心肌细胞的保护作用及其机制 [J]．吉林大学学报：医学版， 2018 ， 44 ( 5 )： 974 - 978 ．

Dhapare S , Sakagami M . Salvianolic acid B as an anti-emphysema agent I: in vitro stimulation of lung cell proliferation and migration, and protection against lung cell death, and in vivo lung STAT3 activation and VEGF elevation [J]. Pulm Pharmacol Ther , 2018 , 53 : 107 - 115 .

CHEN H M , LUO H , ZENG W B , et al . Salvianolic acid B attenuates oxidized low-density lipoprotein-induced endothelial cell apoptosis through inhibition of oxidative stress, p53, and caspase-3 pathways [J]. Chin J Integr Med , 2017 , 24 ( 10 ): 016 - 2645 .

TAO S , REN Y , ZHENG H , et al . Salvianolic acid B inhibits intermittent high glucose-induced INS-1 cell apoptosis through regulation of Bcl-2 proteins and mitochondrial membrane potential [J]. Eur J Pharmacol , 2017 , 814 : 56 - 62 .

甘彩玉，郑作文，梁冰洁，等． PI3K/Akt/p53通路探讨藤茶总黄酮抗肝癌的作用机制 [J]．中国实验方剂学杂志， 2019 ， 25 ( 12 )： 90 - 96 ．

QIAO Z , XU Y . Salvianolic acid B alleviating myocardium injury in ischemia reperfusion rats [J]. Afr J Tradit Complement Altern Med , 2016 , 13 ( 4 ): 157 - 161 .

REN Y N , TAO S J , ZHAO M Q , et al . The effect of salvianolic acid B on the apoptosis of HUVECs induced by intermittent high glucose [J]. Chin Tradit Herb Drugs , 2016 , 39 ( 8 ): 1843 - 1848 .

Perez-Alvarez M J , Villa Gonzalez M , Benito-Cuesta I , et al . Role of mTORC1 controlling proteostasis after brain ischemia [J]. Front Neurosci , 2018 , doi: 10.3389/fnins.2018.00060 http://doi.org/10.3389/fnins.2018.00060 .

LIN J , LIN R , LI S , et al . Salvianolic acid B promotes the survival of random-pattern skin flaps in rats by inducing autophagy [J]. Front Pharmacol , 2018 , doi: 10.3389/fphar.2018.01178 http://doi.org/10.3389/fphar.2018.01178 .

YANG G , WANG N , Seto S W , et al . Hydroxysafflor yellow a protects brain microvascular endothelial cells against oxygen glucose deprivation/reoxygenation injury: involvement of inhibiting autophagy via class I PI3K/Akt/mTOR signaling pathway [J]. Brain Res Bull , 2018 , 140 : 243 - 257 .

WU P , YUAN X , LI F , et al . Myocardial upregulation of cathepsin d by ischemic heart disease promotes autophagic flux and protects against cardiac remodeling and heart failure [J]. Circ Heart Fail , 2017 , 10 ( 7 ): 10 .

Zaffagnini G , Savova A , Danieli A , et al . p62 filaments capture and present ubiquitinated cargos for autophagy [J]. Embo J , 2018 , doi: 10.15252/embj.201798308 http://doi.org/10.15252/embj.201798308 .

刘晓龙，崔子林，李阳，等．丹酚酸B对脓毒症大鼠心肌损伤的保护作用 [J]．中国实验方剂学杂志， 2019 ， 25 ( 14 )： 112 - 118 ．

GAO S , LI S , LI Q , et al . Protective effects of salvianolic acid B against hydrogen peroxideinduced apoptosis of human umbilical vein endothelial cells and underlying mechanisms [J]. Int J Mol Med , 2019 , doi: 10.3892/ijmm.2019.4227 http://doi.org/10.3892/ijmm.2019.4227 .

苏成福，龚曼，韩永光，等．葛根总黄酮对氧化应激损伤人脐静脉内皮细胞的保护作用及其机制 [J]．中国实验方剂学杂志， 2018 ， 24 ( 23 )： 159 - 164 ．

MA Y , LI W , YIN Y . AST IV inhibits H(2)O(2)-induced human umbilical vein endothelial cell apoptosis by suppressing Nox4 expression through the TGF-beta1/Smad2 pathway [J]. Int J Mol Med , 2015 , 35 ( 6 ): 1667 - 1674 .

LIU Q , SHI X , TANG L , et al . Salvianolic acid B attenuates experimental pulmonary inflammation by protecting endothelial cells against oxidative stress injury [J]. Eur J Pharmacol , 2018 , doi: 10.1016/j.ejphar.2018.09.030 http://doi.org/10.1016/j.ejphar.2018.09.030 .

LIU B , CAO B , ZHANG D , et al . Salvianolic acid B protects against paraquat-induced pulmonary injury by mediating Nrf2/Nox4 redox balance and TGF-beta1/Smad3 signaling [J]. Toxicol Appl Pharmacol , 2016 , 309 : 111 - 120 .

张旭，朱元美，唐保露，等．丹酚酸B对糖尿病大鼠肾纤维化的改善作用及其机制 [J]．中国药理学通报， 2019 ， 35 ( 1 )： 51 - 55 ．

Diomede F , Zingariello M , Cavalcanti M , et al . MyD88/ERK/NFkB pathways and pro-inflammatory cytokines release in periodonment stem cells stimulated by Porphyromonas gingivalis [J]. Eur J Histochem , 2017 , 61 ( 2 ): 2791 .

MA Z G , XIA H Q , CUI S L , et al . Attenuation of renal ischemic reperfusion injury by salvianolic acid B via suppressing oxidative stress and inflammation through PI3K/Akt signaling pathway [J]. Braz J Med Biol Res , 2017 , 50 ( 6 ): e5954 .

YANG K , ZHANG H , LUO Y , et al . Gypenoside XVII prevents atherosclerosis by attenuating endothelial apoptosis and oxidative stress: insight into the eralpha-mediated PI3K/Akt pathway [J]. Int J Mol Sci , 2017 , 18 ( 2 ): E77 .

Carlson C G , Dole E , Stefanski C , et al . The effect of specific IKKbeta inhibitors on the cytosolic expression of IkappaB-alpha and the nuclear expression of p65 in dystrophic (MDX) muscle [J]. Am J Transl Res , 2015 , 7 ( 4 ): 670 - 682 .

XIA Z B , YUAN Y J , ZHANG Q H , et al . Salvianolic acid B suppresses inflammatory mediator levels by downregulating NF-kappaB in a rat model of rheumatoid arthritis [J]. Med Sci Monit , 2018 , doi: 10.12659/MSM.907084 http://doi.org/10.12659/MSM.907084 .

赵梦秋，任尤楠，陶善珺，等．丹酚酸B对糖尿病大鼠血管舒张功能、NF-κB活化及炎症因子表达的影响 [J]．中国病理生理杂志， 2018 ， 34 ( 3 )： 481 - 487 ．

WANG S X , HU L M , GAO X M , et al . Anti-inflammatory activity of salvianolic acid B in microglia contributes to its neuroprotective effect [J]. Neurochem Res , 2010 , 35 ( 7 ): 1029 - 1037 .

XU S , ZHONG A , BU X , et al . Salvianolic acid B inhibits platelets-mediated inflammatory response in vascular endothelial cells [J]. Thromb Res , 2015 , 135 ( 1 ): 137 - 145 .

Stepkowski T M , Kruszewski M K . Molecular cross-talk between the NRF2/KEAP1 signaling pathway, autophagy, and apoptosis [J]. Free Radic Biol Med , 2011 , 50 ( 9 ): 1186 - 1195 .

张敏，许成辰，徐婷贞，等．基于Nrf2/Keap1/p62信号通路探讨百合固金汤对LPS诱导的小鼠急性肺损伤的保护作用 [J]．中国实验方剂学杂志， 2019 ， 25 ( 15 )： 77 - 82 ．

DENG C , SUN Z , TONG G , et al . Alpha-lipoic acid reduces infarct size and preserves cardiac function in rat myocardial ischemia/reperfusion injury through activation of PI3K/Akt/Nrf2 pathway [J]. PLoS One , 2013 , 8 ( 3 ): e58371 .

Suh J H , Shenvi S V , Dixon B M , et al . Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid [J]. Proc Natl Acad Sci USA , 2004 , 101 ( 10 ): 3381 - 3386 .

Smith A R , Hagen T M . Vascular endothelial dysfunction in aging: loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration by (R)-alpha-lipoic acid [J]. Biochem Soc Trans , 2003 , 31 ( 6 ): 1447 - 1449 .

CHEN L , LI Y , YIN W , et al . Combination of chlorogenic acid and salvianolic acid B protects against polychlorinated biphenyls-induced oxidative stress through Nrf2 [J]. Environ Toxicol Pharmacol , 2016 , doi: 10.1016/j.etap.2016.08.004 http://doi.org/10.1016/j.etap.2016.08.004 .

ZHANG X , WU Q , LU Y , et al . Cerebroprotection by salvianolic acid B after experimental subarachnoid hemorrhage occurs via Nrf2-and SIRT1-dependent pathways [J]. Free Radic Biol Med , 2018 , 124 : 504 - 516 .

LIU M , XU H , ZHANG L , et al . Salvianolic acid B inhibits myofibroblast transdifferentiation in experimental pulmonary fibrosis via the up-regulation of Nrf2 [J]. Biochem Biophys Res Commun , 2018 , 495 ( 1 ): 325 - 331 .

ZHANG X S , WU Q , WU L Y , et al . Sirtuin 1 activation protects against early brain injury after experimental subarachnoid hemorrhage in rats [J]. Cell Death Dis , 2016 , 7 ( 10 ): 292 .

HUANG M Q , ZHOU C J , ZHANG Y P , et al . Salvianolic acid B ameliorates hyperglycemia and dyslipidemia in db/db mice through the AMPK pathway [J]. Cell Physiol Biochem , 2016 , 40 ( 5 ): 933 - 943 .

LIU T Q , LIU S P , YU X F , et al . Salvianolic acid B prevents iodinated contrast media-induced acute renal injury in rats via the PI3K/Akt/Nrf2 pathway [J]. Oxid Med Cell Longev , 2016 , doi: 10.1155/2016/7079487 http://doi.org/10.1155/2016/7079487 .

LV H , WANG L , SHEN J , et al . Salvianolic acid B attenuates apoptosis and inflammation via SIRT1 activation in experimental stroke rats [J]. Brain Res Bull , 2015 , 115 : 30 - 36 .

WANG Y , CHEN J , KONG W , et al . Regulation of SIRT3/FOXO1 signaling pathway in rats with non-alcoholic steatohepatitis by salvianolic acid B [J]. Arch Med Res , 2017 , 48 ( 6 ): 506 - 512 .

陈小青，任俞霏，孔维宗，等．丹酚酸B对非酒精性脂肪性肝病细胞模型氧化应激的影响 [J]．临床肝胆病杂志， 2018 ， 34 ( 10 )： 2175 - 2181 ．

Kleiner D E , Brunt E M , Van Natta M , et al . Design and validation of a histological scoring system for nonalcoholic fatty liver disease [J]. Hepatology , 2005 , 41 ( 6 ): 1313 - 1321 .

ZHANG Y F , XU L W , LIANG K , et al . Protective effect of salvianolic acid B against oxidative injury associated with cystine stone formation [J]. Urolithiasis , 2019 , 18 ( 10 ): 019 - 01114 .

LIU Y , HU Y , E Q , et al . Salvianolic acid B inhibits mitochondrial dysfunction by up-regulating mortalin [J]. Sci Rep , 2017 , doi: 10.1038/srep43097 http://doi.org/10.1038/srep43097 .

Tibullo D , Li Volti G , Giallongo C , et al . Biochemical and clinical relevance of alpha lipoic acid: antioxidant and anti-inflammatory activity, molecular pathways and therapeutic potential [J]. Inflamm Res , 2017 , 66 ( 11 ): 947 - 959 .

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