Objective:

2

To observe the clinical efficacy of modified Zhishi Daozhiwan on slow transit constipation (STC) and the effect on gastrointestinal hormones and intestinal flora.

Method:

2

One hundred and sixty patients were randomly divided into control group and observation group by random number table. Patients in control group got Maren Wan

1-2 pills/time

2 times/days

and mosapride citrate tablets

1 piece/time

3 times/days. Patients in observation group got modified Zhishi Daozhiwan

1 dose/day. A course of treatment was 4 weeks. Before and after treatment

the main symptoms of constipation and patient assessment of constipation symptoms (PAC-SYM) were scored. And times of spontaneous complete bowel movement (SCBM) and colonic transmission test were recorded. And levels of intestinal flora and motilin (MTL)

vasoactive intestinal peptide (VIP)

substance P (SP) and gastrin (GAS) were detected. The 12-week follow-up of patients (SCBM≥3) was recorded

and the relapse of disease was calculated.

Result:

2

According to rank sum test analysis

the clinical efficacy in observation group was better than that in control group (

Z

=2.275

P

<

0.05). After treatment

scores of the main symptoms of constipation

PAC-SYM

and the total score of PAC-SYM were all lower than those in control group (

P

<

0.01). At the second

third and fourth weeks after treatment

the times of SCBM were more than those in control group (

P

<

0.01). Ratio of residual marker at 24

48 and 72 h was lower than that in control group (

P

<

0.01). Count of enterococcus and enterobacter were lower than those in control group (

P

<

0.01)

while counts of bifidobacterium and lactobacillus were higher than in control group (

P

<

0.01). Levels of GAS

MTL and SP were higher than those in control group

whereas level of VIP was lower than that in control group (

P

<

0.01). And relapse rate in observation group was 33.85%

which was lower than 57.69% in control group (

χ

2

=6.653

P

<

0.05).

Conclusion:

2

Modified Zhishi Daozhiwan can alleviate constipation and other symptoms

increase the number of SCBM

regulate gastrointestinal hormones and intestinal flora

and improve colonic transit function

with a good clinical efficacy and low recurrence rate

so it is worth clinical application.