Objective:

2

To compare the pharmacodynamic effects of pith-nodecayed and pith-decayed products of Scutellariae Radix on rats with large intestine damp-heat syndrome

and to demonstrate the scientificness of dividing Scutellariae Radix into pith-nodecayed and pith-decayed products as medicines by modern pharmacological test.

Method:

2

Rats were randomly divided into blank group

model group

low-and high-dose group of pith-nodecayed products (0.9

3.6 g·kg

-1

)

low-and high-dose group of pith-decayed products (0.9

3.6 g·kg

-1

)

Scutellariae Radix group (0.9 g·kg

-1

)

compound berberine tablets group (positive drug group

0.045 g·kg

-1

)

and 8 rats in each group. Taking model rats with large intestine damp-heat syndrome

the body temperature

thymus index

spleen index

pathological sections of colon and ileum

inflammatory factors and Secretory immunoglobulin (SIg) A content were selected as indexes to evaluate the therapeutic effect of pith-nodecayed and pith-decayed products on large intestine damp-heat syndrome

and make comprehensive evaluation of the difference in efficacy between them. Partial least squares-discriminant analysis (PLS-DA) was employed to analyze the pharmacological indexes of these two products against large intestine damp-heat syndrome.

Result:

2

Pith-nodecayed and pith-decayed products of Scutellariae Radix with different doses could reduce the body temperature

thymus index

spleen index

contents of interleukin (IL)-2

IL-6

IL-1

β

in serum and SIgA content in intestinal mucosa

and most of them had significant differences (

P

<

0.05

P

<

0.01). Compared with the isodose group of pith-decayed products

the effect of corresponding dose group of pith-nodecayed products was better

and most of them had significant differences (

P

<

0.05

P

<

0.01). PLS-DA results indicated that there were significant differences in the pharmacological effects of pith-nodecayed and pith-decayed products

and they were clustered on one side

respectively.

Conclusion:

2

Both of pith-nodecayed and pith-decayed products of Scutellariae Radix have therapeutic effect on large intestine damp-heat syndrome with distinctly different strength of action

and pith-nodecayed products is superior to pith-decayed products

which verify the scientific nature of pith-nodecayed products was specializedly used to treat bowel disease in ancient times.