Objective:

2

To observe the effect of modified Erxian decoction on the physical condition

pain in the lower back and joints

limb activity

bone density

bone metabolism and biochemical indexes in patients with osteoporosis caused by Yang deficiency

in order to explore the possible mechanism.

Method:

2

Totally 100 cases of osteoporosis with Yang deficiency were randomly divided into treatment group and control group

with 50 cases in each group. The control group was treated with basic anti-osteoporosis therapy

and the treatment group was give modified Erxian decoction combined with basic therapy for 6 weeks. Short physical performance battery (SPPB) scores of low back and joint pain and Yang deficiency symptom score before and after treatment were recorded and analyzed. before and after treatment

the changes of blood serum calcium (Ca)

phosphorus (P)

L

1-4

femoral neck bone mineral density(BMD)

osteocalcin (BGP) and type I collagen peptide amino end level (P1NP) were measured.

Result:

2

The scores of lumbar back and joint pain

Yang deficiency symptom score

limb function and activity

lumbar spine 1-4 (L

1-4

)

femoral neck BMD

Ca

P

BGP and P1NP between two groups before treatment had no statistically significant difference. After 6 weeks of treatment

limb activity score

L

1-4

femoral neck BMD

serum Ca and P levels in treatment group were significantly higher than those in control group (

P

<

0.05). The scores of the pain in the lower back and joints

Yang deficiency symptom score

BGP and P1NP in treatment group were significantly lower than those in control group (

P

<

0.05).

Conclusion:

2

Modified Erxian decoction can significantly alleviate the pain in the lower back and joints of patients with osteoporosis caused by Yang deficiency

enhance the limb function and activity status

improve the physical condition and bone density of patients

reduce bone conversion

with a good effect in treating and alleviating symptoms of osteoporosis caused by Yang deficiency.