Objective:

2

To discuss the clinical efficacy of Liuwei Dihuangwan combined with Danzi Xiaoyaosan on H-type hypertension with syndrome of Yin deficiency and Yang hyperactivity and its effect on vascular endothelial function and inflammatory factors.

Method:

2

One hundred and fifty patients were randomly divided into control group (75 cases) and observation group (75 cases) by random number table.Patients in control group got enalapril maleate and folic acid tablets

1 tablet/time

1 time/day

and patients with uncontrollable blood pressure were also given nifedipine sustained-release tablets

20-30 mg/time

2 times/days.In addition of the therapy of control group

patients in observation group were also given modified Liuwei Dihuangwan combined with Danzi Xiaoyaosan

1 dose/day.The course of treatment was 12 weeks.Before and after treatment

systolic blood pressure (SBP)

diastolic blood pressure (DBP) and up-to-standard blood pressure were detected.And ambulatory blood pressure

standard deviation of 24-hours systolic blood pressure (24 h SSD)

standard deviation of 24-hour diastolic blood pressure 24 h DSD)

24 h mean systolic blood pressure (24 h SBP)

24 h mean diastolic blood pressure (24 h DBP) were recorded.And ankle brachial index (ABI) and brachial artery blood flow mediated diamete (FMD) were discussed

syndrome of Yin deficiency and Yang hyperactivity was scored

and levels of iterleukin-6 (IL-6)

IL-10

high-sensitivity C-reactive protein (hsCRP) and homocysteine (Hcy) were detected.

Result:

2

The levels of SBP

DBP

24 h SSD

24 h DSD

24 h SBP and 24 h DBP were all lower than those in control group (

P

<

0.01). The achievement rate of accidental blood pressure in observation group was 81.19%

which was higher than 66.98% in control group (

χ

2

=29.81

P

<

0.01). And levels of ABI

FMD and IL-10 were higher than those in control group (

P

<

0.01)

while the score of syndrome of Yin Deficiency and Yang Hyperactivity and the levels of Hcy

leptin

IL-6 and hs-CRP were lower than those in control group (

P

<

0.01).

Conclusion:

2

In addition to the therapy of antihypertensive and folic acid

Liuwei Dihuangwan combined with Danzi Xiaoyaosan can be given to control the level of blood pressure and Hcy

relieve the variability of blood pressure

alleviate clinical symptoms

raise the rate of achievement rate of blood pressure

improve the function of vascular endothelium

and regulate inflammatory factors.