心力衰竭底物代谢重构模式及其机制的研究进展

成文堃; 赵明镜; 王蕾; 陆梓雯; 杨涛; 杨京京; 李彤; 王保福; 李洋

doi:10.13422/j.cnki.syfjx.20200108

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心力衰竭底物代谢重构模式及其机制的研究进展

综述 | 更新时间：2021-02-09

- 心力衰竭底物代谢重构模式及其机制的研究进展
- Myocardial Substrate Metabolic Remodeling in Heart Failure
- 中国实验方剂学杂志 2020年26卷第5期页码：210-219
- 作者机构：
  
  北京中医药大学　东直门医院　中医内科学教育部和北京市重点实验室，中西医结合气血研究实验室，北京　 100700
- 作者简介：
  
  [第一作者]　成文堃，在读博士，从事中西医结合心血管疾病应用基础研究，Tel：010-84013190，E-mail：471097730@qq.com
  *赵明镜，研究员，博士生导师，从事中西医结合防治心脑血管病研究，Tel：010-84013190，E-mail：mjgx2004@163.com
- 基金信息：
  
  国家自然科学基金项目(81541075);北京市自然科学基金重点项目(7161008)
- DOI：10.13422/j.cnki.syfjx.20200108
  中图分类号： R2-0; R22; R285.5; R284.1
- 收稿日期：2019-06-27，
  
  网络出版日期：2019-09-11，
  
  纸质出版日期：2020-03-05
- 稿件说明：
移动端阅览
成文堃, 赵明镜, 王蕾, 等. 心力衰竭底物代谢重构模式及其机制的研究进展[J]. 中国实验方剂学杂志, 2020,26(5):210-219.

Wen-kun CHENG, Ming-jing ZHAO, Lei WANG, et al. Myocardial Substrate Metabolic Remodeling in Heart Failure[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(5): 210-219.
成文堃, 赵明镜, 王蕾, 等. 心力衰竭底物代谢重构模式及其机制的研究进展[J]. 中国实验方剂学杂志, 2020,26(5):210-219. DOI： 10.13422/j.cnki.syfjx.20200108.

Wen-kun CHENG, Ming-jing ZHAO, Lei WANG, et al. Myocardial Substrate Metabolic Remodeling in Heart Failure[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(5): 210-219. DOI： 10.13422/j.cnki.syfjx.20200108.

摘要

心力衰竭后心肌底物代谢严重受损，对葡萄糖和脂肪酸等底物的选择和利用发生重构，心肌产能不足，可导致心功能障碍和进展性左心室重构。传统观念认为，心衰时心脏从脂肪酸代谢向葡萄糖代谢转化，但近年来有些研究结果与此观点相矛盾，关于心衰后心肌能量底物代谢的改变及其调控机制的研究结论尚未统一，心衰的代谢治疗发展缓慢，因此，探讨导致这些结论异质性的原因对明确心衰底物代谢模式和研发代谢靶向药物十分必要。该综述总结了正常心肌在生理条件下的代谢模式及调控机制，同时，从心衰的病因、严重程度、持续时间、研究的物种、动物模型和代谢检测方法等多个角度，重点阐述和比较了由缺血性心脏病、压力负荷、容量负荷及扩张型心肌病诱导的心衰中心脏底物代谢的异常，初步分析了不同研究中相关结论的一致性和差异性，并对代谢治疗的未来趋势展开论述，以期初步总结出心衰后葡萄糖代谢和脂肪酸代谢变化的规律及其分子机制，并为代谢靶向治疗的研究提供线索。

Abstract

Myocardial substrate metabolism is severely impaired after heart failure

and the selection and utilization of substrates

such as glucose and fatty acids

are remodeled

resulting in insufficient myocardial productivity

cardiac dysfunction and progressive left ventricular remodeling. It is believed traditionally that the heart changes from fatty acid metabolism to glucose metabolism during heart failure

which however is contradictory with some findings in recent years. No consistent conclusion can be drawn from studies on the changes of myocardial energy substrate metabolism and its regulatory mechanism after heart failure. Metabolic treatment for heart failure has developed slowly. Therefore

it is necessary to explore the reasons for heterogeneity of these conclusions for defining the metabolic patterns of heart failure substrates and developing metabolically targeted drugs. This review summarizes the metabolic patterns and regulatory mechanisms of normal myocardium under physiological conditions

focuses on the elaboration and comparison of myocardial substrates metabolic abnormalities in heart failure induced by ischemic heart disease

pressure load

volume load and dilated cardiomyopathy in such aspects as etiology

severity

duration of heart failure

species studied

animal models and metabolic detection methods

and makes a preliminary analysis on the consistency and differences of relevant conclusions in various studies

and discusses the future trend of metabolic treatment

with the aim to summarize the rules and molecular mechanism of glucose metabolism and fatty acid metabolism after heart failure and provide clues for the research of metabolic targeted therapy.

关键词

Keywords

references

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