治胃丸治疗Hp相关性胃炎肝胃气滞证的临床观察

肖淑红; 刘建浩; 刘德喜; 薛娟

doi:10.13422/j.cnki.syfjx.20200134

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治胃丸治疗Hp相关性胃炎肝胃气滞证的临床观察

临床 | 更新时间：2021-02-09

- 治胃丸治疗Hp相关性胃炎肝胃气滞证的临床观察
- Clinical Observation of Zhiwei Pills for Gastritis Caused by Helicobacter Pylori with Syndrome of Stagnation in Liver and Stomach Qi
- 中国实验方剂学杂志 2020年26卷第6期页码：91-96
- 作者机构：
  
  1.三亚市中医院，海南三亚　 572000
  2.中南大学　湘雅医院，长沙　 410013
- 作者简介：
  
  [第一作者]　肖淑红，从事中医内科的临床工作，E-mail：hainxiao888@163.com
  *刘德喜，主任医师，从事中医消化内科的临床工作，E-mail：liudexi0011@163.com
- 基金信息：
  
  海南自然科学基金面上项目(817399);国家中医药管理局国家临床重点专科（中医专业）建设项目(352)
- DOI：10.13422/j.cnki.syfjx.20200134
  中图分类号： R25; R256; R256.3; R289
- 收稿日期：2019-08-08，
  
  网络出版日期：2019-10-21，
  
  纸质出版日期：2020-03-20
- 稿件说明：
移动端阅览
肖淑红, 刘建浩, 刘德喜, 等. 治胃丸治疗Hp相关性胃炎肝胃气滞证的临床观察[J]. 中国实验方剂学杂志, 2020,26(6):91-96.

Shu-hong XIAO, Jian-hao LIU, De-xi LIU, et al. Clinical Observation of Zhiwei Pills for Gastritis Caused by Helicobacter Pylori with Syndrome of Stagnation in Liver and Stomach Qi[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(6): 91-96.
肖淑红, 刘建浩, 刘德喜, 等. 治胃丸治疗Hp相关性胃炎肝胃气滞证的临床观察[J]. 中国实验方剂学杂志, 2020,26(6):91-96. DOI： 10.13422/j.cnki.syfjx.20200134.

Shu-hong XIAO, Jian-hao LIU, De-xi LIU, et al. Clinical Observation of Zhiwei Pills for Gastritis Caused by Helicobacter Pylori with Syndrome of Stagnation in Liver and Stomach Qi[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(6): 91-96. DOI： 10.13422/j.cnki.syfjx.20200134.

摘要

目的：

评价治胃丸配合幽门螺杆菌(Hp)根除方案治疗Hp胃炎(肝胃气滞证)的临床疗效及抗炎和抗氧化应激作用。

方法：

将160例患者随机数字表法，按1∶1分为对照组和观察组各80例。对照组给予Hp根除方案，口服艾司奥美拉唑镁肠溶片，20 mg/次，1次/d；和枸橼酸铋钾片，0.3 g /次，2次/d；和阿莫西林胶囊，1.0 g/次，2次/d；和呋喃唑酮片，0.1 g/次，2次/d，共服14 d。观察组在对照组治疗的基础上口服治胃丸，6 g/次，3次/d。两组疗程均为连续治疗8周。检测治疗后Hp根除情况，进行治疗前后肝胃气滞证评分，治疗后胃镜及病理复查，及治疗前后患者报告结局指标(PRO)评价；检测治疗前后肿瘤坏死因子-

(TNF-

)，白细胞介素-1

(IL-1

)，IL-8，氧化物歧化酶(SOD)，谷胱甘肽过氧化物酶(GSH-Px)，丙二醛(MDA)水平。

结果：

观察组Hp阴转率为(70/75)93.33%，高于对照组的(58/71)81.69%(

0.05)；中医证候疗效经秩和检验分析，观察组优于对照组(

＝2.183，

0.05)；临床疗效经秩和检验分析，观察组临床疗效优于对照组(

＝2.175，

0.05)；观察组患者肝胃气滞证积分和PRO总分均低于对照组(

0.01)；观察组患者血清TNF-

，IL-1

和IL-8水平均低于对照组(

0.01)；观察组SOD，GSH-Px均高于对照组(

0.01)，MDA低于对照组(

0.01)。

结论：

治胃丸配合Hp根除方案治疗Hp胃炎肝胃气滞证患者，可提高Hp根除率，减轻临床症状，并能提高患者的生活质量，具有抑制炎症反应和抗氧化应激作用，提高了中医证候疗效和临床疗效，值得进一步的研究和使用。

Abstract

Objective:

To evaluate theclinical efficacy of Zhiwei pills combined with Hperadication programme for gastritis with liver and stomach Qi stagnation syndrome caused by helicobacter pylori (Hp) and to investigate its effect on antioxidant stress.

Method:

One hundred and sixty patients were randomly divided into control group (80 cases) and observation group (80 cases) by random number table. Patients in control group gotHperadication programme

and esomeprazole magnesium enteric-coated tablets

20 mg/time

1 time/day. Bismuth potassium citrate tablets

0.3 g/time

2 times/days. Amoxicillin capsules

1.0 g/time

0.1 g/time

2 times/days

all for 14 days. Based on the treatment in control group

the patients in observation group additionally got Zhiwei pills

6 g/time

3 times/day. The course of treatment was 8 weeks in both groups. After treatment

eradication of Hp was detected. Before and after treatment

scores of liver and stomach Qi stagnation syndrome were graded. After treatment

patients received gastroscopy and pathological review

and patient report outcome indicators (PRO) both before and after treatment were discussed. The levels of tumor necrosis factor-

(TNF-

)

interleukin-1

(IL-1

)

IL-8

oxidative dismutase (SOD)

glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) were detected both before and after treatment.

Result:

Negative conversion rate of Hp was(70/75) 93.33% in observation group

higher than(58/71) 81.69% in control group (

0.05). In the analysis of rank sum test

effect of traditional Chinese medical(TCM) syndrome in observation group was better than that in control group (

=2.183

0.05)

and clinical efficacy was also better than that in control group (

=2.175

0.05). Scores of liver and stomach Qi stagnation syndrome and total PRO score in observation group were all lower than those in control group (

0.01). Levels of TNF-

IL-1

IL-8 and MDA were lower than those in control group (

0.01)

while levels of SOD and GSH-Px were higher than those in control group (

0.01).

Conclusion:

Zhiwei pills combined with Hperadication programme can improve the eradication rate of Hp

alleviate clinical symptoms

improve the quality of life of patients

inhibit inflammatory reaction and anti-oxidative stress

and improve the curative effect and clinical efficacy of TCM syndromes in the treatment of gastritis with liver and stomach Qi stagnation syndrome

so it is worth for further study and use.

关键词

Keywords

references

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