Objective

2

To observe the clinical efficacy and safety of modified Chaihu Jia Longgu Muli Tang in treating mild to moderate essential hypertension complicated with depression and liver-Yang hyperactivity syndrome.

Method

2

Totally 121 mild to moderate hypertensive patients complicated with depression in line with the inclusive criteria were randomized into treatment group and control group. All of the enrolled patients in treatment group and control group were treated with conventional therapy. In treatment group

patients were given modified Chaihu Jia Longgu Muli Tang

one dose per day. The treatment course lasted for 4 weeks. Blood pressure

patient health questionnaire-9 (PHQ-9) score

score of traditional Chinese medicine syndrome

C-reactive protein (CRP)

endothelial-dependent vasodilation

and adverse effect were observed in this study.

Result

2

Both systolic blood pressure and diastolic blood pressure were significantly lowered when compared to control group (

P

<

0.05). PHQ-9 score was significantly improved in treatment group (

P

<

0.05). The score of traditional Chinese medicine syndrome was significantly improved in treatment group compared to control group (

P

<

0.05). CRP was significantly improved in treatment group compared with control group (

P

<

0.05). Endothelial-dependent vasodilation was significantly improved in treatment group compared with control group (

P

<

0.05). No severe adverse effect was observed in this research.

Conclusion

2

Chaihu Jia Longgu Muli Tang has a creation clinical efficacy in the treatment of mild to moderate essential hypertension with depression. In addition to the effect in reducing both systolic and diastolic blood pressure

modified Chaihu Jia Longgu Muli Tang was also effective in improving depression

traditional Chinese medicine syndrome and endothelial-dependent vasodilation

and reducing the level of CRP with little adverse effect.