Objective:

2

Through the retrospective study of Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) patients

the clinical features and the characteristics of traditional Chinese medicine (TCM) syndrome distribution of HBV-ACLF complicated with bacterial infection were preliminarily expounded

so as to provide the corresponding theoretical basis for the diagnosis and treatment of HBV-ACLF secondary bacterial infection.

Method:

2

A unified data collection form for patients with slow plus acute liver failure was designed by the retrospective epidemiological investigation method. The clinical data of 307 patients with HBV-ACLF who were hospitalized at the Hepatology Institute of the First Affiliated Hospital of Hunan University of Chinese Medicine were collected in strict accordance with the inclusion and exclusion standards

and the main symptoms and the TCM symptoms were screened. Then

according to whether or not there was a bacterial infection

the patients were divided into a combined bacterial infection group and a non-combined bacterial infection group. The distribution characteristics of the main symptoms and the TCM symptoms in two groups were compared

and the distribution characteristics of TCM symptoms of HBV-ACLF with bacterial infection were obtained.

Result:

2

Compared with patients with uncombined bacterial infection

patients with combined bacterial infection had significantly increased abdominal distension

puffiness

purple and dark tongue color

abdominal varicose tendons

subcutaneous stasis spots

and tooth marks on the side of the tongue. Compared with patients with combined bacterial infections

patients with uncombined bacterial infections mainly showed bright yellow head

yellow tongue coating

and significantly increased dry mouth (

P

<

0.05

P

<

0.01). The main symptoms of patients with combined bacterial infections was the combination of syndrome (93.6%)

and more spleen deficiency syndrome (81.6%)

patients with uncombined bacterial infections mainly suffered from a single syndrome (53.5%)

which was mostly damp-heat syndrome (51.9%)

patients of concurrent syndrome with combined bacterial infections mostly suffered from false and real syndrome (94.4%)

which was significantly higher than those with uncombined bacterial infections (58.9%).

Conclusion:

2

The patients with HBV-ACLF without bacterial infection mainly suffered from damp-heat symptoms and signs. With the combination of bacterial infection

the symptoms and signs of spleen deficiency and blood stasis gradually worsened. HBV-ACLF patients with bacterial infection mainly suffered from spleen deficiency and blood stasis

while patients with unincorporated bacterial infection mainly suffered from the single damp-heat symptoms and signs.