Objective

2

To observe clinical effect of addition and subtraction therapy of Si Junzitang combined with Simotang to outlet obstructive constipation (OOC) after stapled trans-anal rectal resection (STARR).

Method

2

One hundred and twenty-four patients were randomly divided into control group (62 cases) and observation group (62 cases) by random number table. Patients in control group got Qirong Ruichang oral liquid

20 mL/time

3 times/day. After operation

patients in observation group got addition and subtraction therapy of Si Junzitang combined with Simotang

1 dose/day. And courses of treatment in two groups were 4 weeks

and 8 weeks' follow-up was recorded. Before the operation and at the second and fourth week after treatment

and the eighth week of follow-up

scores of main symptoms of constipation and Longo ODS were graded. Before the operation and at the fourth week after treatment

levels of superoxide dismutase (SOD)

malondialdehyde (MDA)

constipation patients quality of life self-assessment scale (PAC-QOL)

anorectal pressure

anal resting pressure (ARP)

maximum anal systolic pressure (MSP)

rectal defecation pressure (RSP)

FSV

CRS and MTV were recorded. And incidence

recurrence

normal defecation

satisfaction at the fourth week after the operation and safety were evaluated.

Result

2

The clinical rate in observation group was better than that in control group (

Z

=2.096

P

<

0.05). At the second

fourth after treatment and eigh weeks' for follow-up

score of main symptoms of constipation and Longo ODS were both lower than those in control group (

P

<

0.01). Levels of ARP

FSV

FSV

CRS and MDA were lower than those in control group (

P

<

0.01)

levels of MSP

RSP and SOD were higher than those in control group (

P

<

0.01). Incidence and recurrence rate in observation group were 20.97% (13/62) and 4.84% (3/62) were all lower than 39.71% (24/62) and 16.13% (10/62) in control group (

P

<

0.05). Normal defecation rate in observation group was 91.94% (57/62) higher than 80.65% (50/62) in control group

but there was no statistical significance in two groups. And total score of PAC-QOL and scores of each factor were all lower than those in control group (

P

<

0.01). Then there was no adverse reaction related to the traditional Chinese medicine.

Conclusion

2

Addition and subtraction therapy of Si Junzitang combined with Simotang can reduce constipation symptoms and the degree of illness

improve the quality of life

reduce the incidence of postoperative complications and recurrence rate

and improve anorectal dynamic indicators and oxidative stress indicators

improve the clinical efficacy.