苇茎汤合麻杏石甘汤加减联合半量激素治疗儿童毒热闭肺证难治性肺炎支原体肺炎

王书玲; 侯江红; 张岩; 郭彦荣; 李芳

doi:10.13422/j.cnki.syfjx.20201021

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苇茎汤合麻杏石甘汤加减联合半量激素治疗儿童毒热闭肺证难治性肺炎支原体肺炎

临床 | 更新时间：2021-02-09

- 苇茎汤合麻杏石甘汤加减联合半量激素治疗儿童毒热闭肺证难治性肺炎支原体肺炎
- Clinical Efficacy of Modified Weijingtang and Maxing Shigan Tang Combined with Half-dose Hormones on Refractory Mycoplcasma Pneumoniae Pneumonia in Children Caused by Toxic Heat Closing Lung
- 中国实验方剂学杂志 2020年26卷第10期页码：69-74
- 作者机构：
  
  1.河南省中医院，郑州　 450002
  2.河南中医药大学　第一附属医院，郑州　 450009
  3.河南省中医药研究院，郑州　 450004
- 作者简介：
  
  [第一作者]　王书玲，硕士，主治医师，从事中医药防治小儿呼吸疾病研究，E-mail：wangshuling3355@sina.com
  *侯江红，硕士，主任医师，博士生导师，从事中医药调治小儿亚健康状态研究，Tel：0371-60908747，E-mail：yihui2doctor@163.com
- 基金信息：
  
  河南省中医药科学研究专项(2019JDZX085)
- DOI：10.13422/j.cnki.syfjx.20201021
  中图分类号： R22; R242; R2-031;R287
- 收稿日期：2019-09-17，
  
  网络出版日期：2020-02-07，
  
  纸质出版日期：2020-05-20
- 稿件说明：
移动端阅览
王书玲, 侯江红, 张岩, 等. 苇茎汤合麻杏石甘汤加减联合半量激素治疗儿童毒热闭肺证难治性肺炎支原体肺炎[J]. 中国实验方剂学杂志, 2020,26(10):69-74.

Shu-ling WANG, Jiang-hong HOU, Yan ZHANG, et al. Clinical Efficacy of Modified Weijingtang and Maxing Shigan Tang Combined with Half-dose Hormones on Refractory Mycoplcasma Pneumoniae Pneumonia in Children Caused by Toxic Heat Closing Lung[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(10): 69-74.
王书玲, 侯江红, 张岩, 等. 苇茎汤合麻杏石甘汤加减联合半量激素治疗儿童毒热闭肺证难治性肺炎支原体肺炎[J]. 中国实验方剂学杂志, 2020,26(10):69-74. DOI： 10.13422/j.cnki.syfjx.20201021.

Shu-ling WANG, Jiang-hong HOU, Yan ZHANG, et al. Clinical Efficacy of Modified Weijingtang and Maxing Shigan Tang Combined with Half-dose Hormones on Refractory Mycoplcasma Pneumoniae Pneumonia in Children Caused by Toxic Heat Closing Lung[J]. Chinese journal of experimental traditional medical formulae, 2020, 26(10): 69-74. DOI： 10.13422/j.cnki.syfjx.20201021.

摘要

目的：

观察苇茎汤合麻杏石甘汤加减联合半量激素治疗儿童毒热闭肺型难治性肺炎支原体肺炎的临床疗效。

方法：

120例患儿随机分为对照组和观察组，各60例。在基础治疗基础上，对照组给予连花清瘟颗粒＋甲强尼龙(每次10 mg·kg

-1

，2次/日)，观察组给予苇茎汤合麻杏石甘汤加减＋甲强尼龙(每次10 mg·kg

-1

，1次/日)，疗程均为14 d。观察两组治疗前后肺功能指标[最大通气量(MVV)，呼气达峰时间(TPTEF)，第1秒用力呼气容积(FEV

)，呼气达峰容积(VPTEF)]，血浆心肌酶谱[肌酸激酶(CK)，肌酸激酶同工酶(CKMB)，乳酸脱氢酶(LDH)，胫丁酸脱氢酶(HBDH)]

，免疫功能[免疫球蛋白G(IgG)，免疫球蛋白M(IgM)，红细胞免疫复合物(RBC-ICR)，红细胞C3b受体(RBC-C3bR)]，炎性因子[肿瘤坏死因子-

(TNF-

)，

-干扰素(IFN-

)，白细胞介素-13(IL-13)，白细胞介素-17A(IL-17A)]，临床疗效和不良反应。

结果：

研究期间脱落4例。观察组总有效率96.6%(57/59)，高于对照组的84.2%(48/57)(

0.05)。与对照组治疗后比较，观察组MVV，TPTEF，FEV

，VPTEF，RBC-C3bR，IL-13升高(

0.05)；CK，CKMB，LDH，HBDH，IgG，IgM，RBC-ICR，TNF-

，IFN-

和IL-17A降低(

0.05)。观察组不良反应发生率低于对照组(

0.05)。

结论：

苇茎汤合麻杏石甘汤加减联合半量激素可明显改善毒热闭肺型难治性肺炎支原体肺炎患儿的肺功能，心肌酶谱，免疫功能和炎性因子水平，不良反应发生率低。

Abstract

Objective:

To observe the clinical efficacy of modified Weijingtang and Maxing Shigan Tang combined with half-dose hormones in the treatment of mycoplcasma pneumoniae pneumonia in children caused by toxic heat closing lung.

Method:

Totally 120 cases were randomly divided into control group and observation group

with 60 cases in each group. In addition to the basic therapy

control group was given Lianhua Qingwen granules + methanilone (10 mg·kg

-1

2 times/day)

while observation group was given modified Weijingtang and Maxing Shigan Tang + methanilone (10 mg·kg

-1

1 time/day) for 14 days. Lung function indicators [maximal voluntary ventilation (MVV)

time of peak tidal expiratory flow (TPTEF)

forced expiratory volume in one second (FEV

)

volume peak time expiratory flow (VPTEF)]

plasma myocardial enzyme profile [creatine kinase (CK)

creatine kinase isoenzyme (CKMB)

lactate dehydrogenase (LDH)

hydroxybutyric acid dehydrogenase (HBDH)]

immune function [immunoglobulin G (IgG)

immunoglobulin M (IgM)

erythrocyte immune complex (RBC-ICR)

erythrocyte C3b receptor (RBC-C3bR)]

inflammatory factors [tumor necrosis factor-alpha (TNF-

)

gamma-interferon (IFN-

)

interleukin-13 (IL-13)

interleukin-17A (IL-17A)]

clinical efficacy and adverse reactions were observed before and after treatment.

Result:

Four cases fell off during the study period. The total effective rate in observation group was 96.6%(57/59)

which was higher than that in control group 84.2%(48/57

0.05). Compared with control group after treatment

lung function

RBC-C3bR and IL-13 were increased in observation group (

0.05)

while myocardial enzyme spectrum

IgG

IgM

RBC-ICR

TNF-

IFN-

and IL-17A were decreased in observation group (

0.05). The incidence of adverse reactions in observation group was

lower than that in control group(

0.05).

Conclusion:

Modified Weijingtang and Maxing Shigan Tang combined with half-dose hormones can improve lung function

myocardial enzyme profile

immune function and inflammatory factor levels of refractory mycoplasma pneumoniae in children caused by toxic heat closing lung

with a incidence of adverse reactions.

关键词

Keywords

references

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