益胃汤加味方对原发性干燥综合征疲劳症状的影响

葛琳; 姜泉; 张华东; 唐晓颇; 焦娟

doi:10.13422/j.cnki.syfjx.20201222

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益胃汤加味方对原发性干燥综合征疲劳症状的影响

临床 | 更新时间：2020-08-11

- 益胃汤加味方对原发性干燥综合征疲劳症状的影响
- Effect of Modified Yiweitang on Fatigue Symptom of Primary Sjörgren′s Syndrome
- 中国实验方剂学杂志 2020年26卷第12期页码：121-125
- 作者机构：
  
  中国中医科学院广安门医院，北京 100053
- 作者简介：
  
  葛琳，硕士，副主任医师，从事中西医结合风湿病研究，E-mail：gelin1020@qq.com
  姜泉，博士，主任医师，从事中西医结合风湿病研究，E-mail：doctorjq@126.com
- 基金信息：
  
  中国中医科学院第三批优势病种临床研究项目(CACMSO8Y002)
- DOI：10.13422/j.cnki.syfjx.20201222
  中图分类号： R22;R242;R2-031;R287
- 网络出版日期：2020-04-03，
  
  纸质出版日期：2020-06-20
- 稿件说明：
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葛琳,姜泉,张华东等.益胃汤加味方对原发性干燥综合征疲劳症状的影响[J].中国实验方剂学杂志,2020,26(12):121-125.

GE Lin,JIANG Quan,ZHANG Hua-dong,et al.Effect of Modified Yiweitang on Fatigue Symptom of Primary Sjörgren′s Syndrome[J].Chinese Journal of Experimental Traditional Medical Formulae,2020,26(12):121-125.
葛琳,姜泉,张华东等.益胃汤加味方对原发性干燥综合征疲劳症状的影响[J].中国实验方剂学杂志,2020,26(12):121-125. DOI： 10.13422/j.cnki.syfjx.20201222.

GE Lin,JIANG Quan,ZHANG Hua-dong,et al.Effect of Modified Yiweitang on Fatigue Symptom of Primary Sjörgren′s Syndrome[J].Chinese Journal of Experimental Traditional Medical Formulae,2020,26(12):121-125. DOI： 10.13422/j.cnki.syfjx.20201222.

摘要

目的

探讨益胃汤加味对改善原发性干燥综合征（primary sjörgren's syndrome

pSS）气阴两虚、瘀血阻络证患者疲劳症状及免疫学指标的治疗效果。

方法

将116例原发性干燥综合征患者按照随机、对照、单盲法分为治疗组与对照组，每组58例。治疗组给予益胃汤加味方，每日1剂，2次/d；对照组给予硫酸羟氯喹200 mg/次，2次/d，两组均连续治疗24周。比较治疗前后两组患者中医证候疗效、中医疲劳症状积分、疲劳症状视觉模拟评分（visual analogue scale，VAS）以及类风湿因子（rheumatoid factor，RF）与血清免疫球蛋白G（immunoglobulin G，IgG）水平。

结果

治疗后治疗组患者中医证候疗效优于对照组（

=3.712，

0.05）；治疗组中医疲劳积分与疲劳症状视觉模拟评分改善均优于对照组（

0.05）。治疗6个月后，治疗组IgG水平较本组治疗前明显下降（

0.05），与对照组组间比较差异无统计学意义。治疗后两组类风湿因子与本组治疗前比较均无明显下降。治疗组不良反应率1.75%（1/57），对照组不良反应发生率为25.49%（13/51）。

结论

与硫酸羟氯喹相比，益胃汤加味方治疗pSS，可明显改善患者疲劳及总体症状，两者均可降低血清IgG，益胃汤加味方组疗效较硫酸羟氯喹更明显。两组药物对pSS患者RF水平均无明显影响。长期用药，益胃汤加味方治疗pSS较硫酸羟氯喹更为安全。

Abstract

Objective

To observe the effect of modified Yiweitang on fatigue symptom and immunological indicators in primary Sjörgren′s Syndrome (pSS).

Method

By random

control

single-blind method

116 cases of patients with pSS were divided into treatment group and control group

with 58 cases in each group. The treatment group was given modified Yiweitang

a dose a day

twice a day， and the control group was given hydroxychloroquine sulfate (HCQ) 200 mg/time

twice a day. The treatment lasted for six months. Visual analogue scale (VAS) of fatigue symptoms

total traditional Chinese medicine (TCM) syndrome score

TCM fatigue score

rheumatoid factor (RF) and serum immunoglobulin G (IgG) were used to compare two groups before and after treatment.

Result

After treatment

the treatment group had a better efficacy on TCM syndromes than control group (

=3.712

0.05). After treatment

the treatment group were superior to control group in improvement of TCM fatigue score and VAS score of fatigue symptom (

0.05). After 6 months of treatment

IgG level in treatment group decreased significantly compared with before treatment

with statistical differences (

0.05)

but no difference between treatment group and control group. After treatment

RF in two groups showed no significant decrease compared with before treatment. The incidence of adverse reactions in the treatment group and the control group were 1.75%（1/57） and 25.49%（13/51）

respectively.

Conclusion

Compared with HCQ

modified Yiweitang can significantly alleviate fatigue and overall symptoms of patients of pSS

both of which can reduce serum IgG

and the efficacy of modified Yiweitang is more obvious than hydroxychloroquine sulfate. Both drugs had no significant effect on RF level of pSS patients. After long-term administration

modified Yiweitang is safer than hydroxychloroquine sulfate in the treatment of pSS.

关键词

Keywords

references

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