Objective

2

To discuss the effect of Arisaema Rhizoma and Pinelliae Pedatisectae Rhizoma on water metabolism and hemorheolog in rats.

Method

2

A total of 50 healthy SD rats were randomly divided into 5 groups

namely normal group

high-dose Arisaema Rhizoma group (1.2 g·kg·d

-1

)

low-dose Arisaema Rhizoma group (1.2 g·kg·d

-1

)

high-dose Pinelliae Pedatisectae Rhizoma group (1.2 g·kg·d

-1

) and low dose Pinelliae Pedatisectae Rhizoma group (0.3 g·kg·d

-1

)

with 10 rats in each group

.

The effects of Arisaema Rhizoma

and

Pinelliae Pedatisectae Rhizoma on water metabolism and hemorheology were compared

with the micturition index

fecal volume

fecal water content

pathological morphology of submandibular gland

aquaporin (AQP2) content in kidney

adenosine cyclic 3′

5′-(hydrogen phosphate)/current good manufacture practices (cAMP/cGMP) and Na

+

-K

+

-ATP enzyme content in serum as the evaluation indexes of water metabolism

and the whole blood viscosity (WBV) and erythrocyte aggregation index (RE) as the evaluation indexes of hemorheolog.

Result

2

Compared with normal group

the fecal volume

fecal water content and AQP2 expression decreased significantly， acinus of submandibular gland were atrophied， micturition index

cAMP/cGMP and Na

+

-K

+

-ATP enzyme content in serum were increased significantly， WBV and RE were increased significantly in high-dose

Arisaema Rhizoma

and

Pinelliae Pedatisectae Rhizoma groups（

P

<

0.05）

but with no significant difference between them.

Conclusion

2

High-dose Arisaema Rhizoma

and

Pinelliae Pedatisectae Rhizoma groups had significant effects on water metabolism and hemorheology in rats

suggesting that attention shall be given to the safety of Arisaema Rhizoma

and

Pinelliae Pedatisectae Rhizoma. And this study provides a theoretical basis for the rational use of the two traditional Chinese medicines in clinic.