基于STAT3/miRNA反馈环路探讨中医药促脑梗死后血管新生的调控机制

杨仁义; 周德生; 傅馨莹; 颜思阳; 龚翠兰; 马强; 刘利娟

doi:10.13422/j.cnki.syfjx.20201862

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基于STAT3/miRNA反馈环路探讨中医药促脑梗死后血管新生的调控机制

综述 | 更新时间：2020-09-16

- 基于STAT3/miRNA反馈环路探讨中医药促脑梗死后血管新生的调控机制
- Regulatory Mechanism of Traditional Chinese Medicine in Promoting Angiogenesis After Cerebral Infarction Based on STAT3/miRNA Feedback Loop
- 中国实验方剂学杂志 2020年26卷第20期页码：221-228
- 作者机构：
  
  1.湖南中医药大学，长沙 410208
  2.湖南中医药大学第一附属医院，长沙 410007
  3.湖南中医药大学附属常德医院，湖南常德 415000
- 作者简介：
  
  杨仁义，硕士，从事神经系统疾病的中医药防治工作，E-mail：792799735@qq.com
  刘利娟，博士，主治医师，从事中医药对脑血管病及其并发症的防治工作，E-mail：601264967@qq.com
- 基金信息：
  
  国家自然科学基金项目(81874463);湖南省科技厅科技创新平台与人才计划项目(2017SK4005);湖南省财政中医药项目名院工程院内优势病种项目(rsk-010-013/006-09);湖南省中医药管理局项目(201824;202046;2020037);湖南省教育厅一般项目(18C0404);湖南中医药大学中西医结合一流学科开放基金项目(2019ZXYJH08)
- DOI：10.13422/j.cnki.syfjx.20201862
  中图分类号： R2-0;R22;R285.5;R289
- 收稿日期：2020-02-29，
  
  网络出版日期：2020-07-23，
  
  纸质出版日期：2020-10-20
- 稿件说明：
移动端阅览
杨仁义,周德生,傅馨莹等.基于STAT3/miRNA反馈环路探讨中医药促脑梗死后血管新生的调控机制[J].中国实验方剂学杂志,2020,26(20):221-228.

YANG Ren-yi,ZHOU De-sheng,FU Xin-ying,et al.Regulatory Mechanism of Traditional Chinese Medicine in Promoting Angiogenesis After Cerebral Infarction Based on STAT3/miRNA Feedback Loop[J].Chinese Journal of Experimental Traditional Medical Formulae,2020,26(20):221-228.
杨仁义,周德生,傅馨莹等.基于STAT3/miRNA反馈环路探讨中医药促脑梗死后血管新生的调控机制[J].中国实验方剂学杂志,2020,26(20):221-228. DOI： 10.13422/j.cnki.syfjx.20201862.

YANG Ren-yi,ZHOU De-sheng,FU Xin-ying,et al.Regulatory Mechanism of Traditional Chinese Medicine in Promoting Angiogenesis After Cerebral Infarction Based on STAT3/miRNA Feedback Loop[J].Chinese Journal of Experimental Traditional Medical Formulae,2020,26(20):221-228. DOI： 10.13422/j.cnki.syfjx.20201862.

摘要

脑梗死是脑血流供应障碍引起脑组织缺血缺氧，出现相应神经功能症状的临床疾病，是最常见的脑血管病之一，严重威胁到人类健康，脑梗死的防治研究具有重要的社会意义。血管新生是脑梗死内科治疗的关键切入点，信号传导和转录激活子（STAT）/缺氧诱导因子-1（HIF-1）/血管内皮生长因子（VEGF）通路是介导脑梗死后血管新生的重要通路。本文以血管新生为切入点，以STAT/HIF-1/VEGF信号通路的上游分子STAT3，微小RNA（miRNA）为主要研究对象，综述芯片测序、实验研究、中医病机、中医治法的研究成果，结合“转录因子（TF）—miRNA”调控模式与“微观整体”思想，提出在中医基础理论指导下立方的中药复方和有效成分可能通过STAT3/miRNA反馈环路激活STAT/HIF-1/VEGF信号通路促脑梗死后血管新生，为中医药治疗脑梗死疾病提出了深层次的分子机制及新的方向。

Abstract

Cerebral infarction is a clinical disease with corresponding neurological symptoms caused by cerebral ischemia and hypoxia caused by cerebral blood supply disorder. It is one of the most common cerebrovascular diseases and a serious threat to human health. The prevention and treatment of cerebral infarction has an important social significance. Angiogenesis is the key starting point for medical treatment of cerebral infarction

and signal transduction and transcriptional activators (STAT)/hypoxia inducing factor-1(HIF-1)/vascular endothelial growth factor (VEGF) pathway are important pathways to mediate angiogenesis after cerebral infarction. This paper took the angiogenesis as the starting point and the upstream molecules of STAT/HIF-1/VEGF signal pathway STAT3 and miRNA as the main study objects

and comprehensively discussed the results of chip sequencing

experimental research

traditional Chinese medicine (TCM) pathogenesis and TCM treatment. Based on the regulatory mode of "TF-miRNA" and the idea of "micro-whole"

it is suggested that under the guidance of the basic theory of TCM

cubic compound prescriptions of TCM and its active components might activate the STAT/HIF-1/VEGF signal pathway through STAT3/miRNA feedback loop to promote angiogenesis after cerebral infarction

which puts forward a deep molecular mechanism and new direction for the treatment of cerebral infarction with TCM.

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references

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