Objective

2

To investigate the therapeutic effect of Qihong capsule on pentobarbital sodium induced heart failure in beagle dogs.

Method

2

Thirty healthy adult beagle dogs were randomly divided into 6 groups

6 in each group. They were normal group

model group

digoxin tablet group (40 μg·kg

-1

)

Qihong capsule high

medium and low dose groups (2.6，1.3，0.65 g·kg

-1

). The heart failure model of beagle dogs was established by intravenous infusion of 2% pentobarbital sodium. The success standard of the model was that the maximum rate of rise of left ventricular pressure was reduced by 70%.The corresponding drugs were given through duodenum. The Ⅱ lead electrocardiogram

coronary blood flow

cardiac output

left ventricular pressure and maximum rate of left ventricular pressure rise were measured by multi-channel physiological recorder. The arterial oxygen content and coronary sinus oxygen content were measured by Roche blood oxygen analyzer at different time points

and the myocardial oxygen utilization rate was calculated.

Result

2

After intravenous infusion of 2% pentobarbital sodium for about 15 minutes

beagle dogs began to show obvious symptoms of heart failure. The main manifestations were the increase of PR interval of Ⅱ lead electrocardiogram

the decrease of coronary blood flow

left ventricular pressure

cardiac output

cardiac output

venous oxygen content

and the increase of myocardial oxygen utilization rate (

P

<

0.01) compared with the model group

Qihong capsule significantly increased coronary blood flow at 60-120 min after treatment (

P

<

0.05). The cardiac output of 2.6 g·kg

-1

Qihong capsule increased significantly at 45-60 min after treatment

with the maximum increase of about 16%

which was significantly different from that of model group (

P

<

0.05). At the same time

it can increase the oxygen content of coronary sinus blood

which indicates that the myocardial oxygen supply is increased and the oxygen utilization rate is decreased. Qihong capsule 1.3 g·kg

-1

group significantly increased the maximum rate of left ventricular pressure rise (

P

<

0.05)

the maximum increase rate was about 42%.

Conclusion

2

Qihong capsule can increase coronary blood flow and venous blood oxygen content at the same time

make myocardial nutrient supply sufficient

reduce oxygen utilization rate

on this basis

Qihong capsule can further increase cardiac output and improve cardiac function

so as to play a protective role in heart failure.