Objective

2

This study aims to investigate the clinical efficacy of Modified Xiangsha Liu Junzitang in the treatment of diabetic gastroparesis （DGP） and its influence on gastrointestinal hormones and oxidative stress.

Method

2

In this study， 128 patients were randomly divided into control group （64 cases） and observation group （64 cases） . Patients in two groups took domperidone tablets orally 30 minutes before meals， 10 mg/time， 3 times/day. Patients in control group took Shenling Baizhusan San， 6 g/time， twice a day. Patients in observation group were prescribed addition and subtraction therapy of Modified Xiangsha Liu Junzitang， 1 dose/day. The course of treatment for both groups was 4 weeks. Before and after treatment， scores of gastroparesis cardinal symptom index （GCSI）， and gastric emptying test and electrogastrogram were noted. Before the treatment， scores of traditional Chinese medicine （TCM） syndrome and health survey summary were graded（SF-36）. The levels of gastrin （GAS）， motilin （MTL）， vasoactive intestinal peptide （VIP）， somatostatin （SS）， superoxide dismutase （SOD）， reactive oxygen species （ROS） and malondialdehyde （MDA） were measured before and after treatment. And adverse reactions during treatment were recorded.

Result

2

The scores of postprandial abdominal distension/early satiety， nausea and vomiting， abdominal distention and the total scores of GCSI in the observation group were lower than those in control group （

P

<

0.01）. The gastric emptying rate in observation group was higher than that in control group （

P

<

0.01）， and the score of TCM syndromes was lower than that of control group （

P

<

0.01）. The scores of SF-36 in observation group were higher than those in control group （

P

<

0.01）. The frequency of gastric electricity and gastric electric vibration before and after the meal in observation group were higher than that in control group （

P

<

0.01）. The levels of GAS， MTL， VIP， ROS and MDA in observation group were lower than those in control group （

P

<

0.01）， while the levels of SS and SOD were higher than that of control group （

P

<

0.01）. The total effective rate in observation group was 93.75% （60/64）， which was higher than 79.69% （51/64） （

χ

2

=5.494，

P

<

0.05） in control group （

P

<

0.01）. And no adverse reactions were found in the clinical observation.

Conclusion

2

Modified Xiangsha Liu Junzitang combined with prokinetic drugs in the treatment of DGP patients can reduce the clinical symptoms of DGP， enhance gastrointestinal motility， improve the gastric emptying rate， improve the quality of life， regulate the level of gastrointestinal hormones， and reduce the damage of autonomic nerve caused by oxidative stress， with good comprehensive clinical effect and safety in application.