
浏览全部资源
扫码关注微信
1.天津中医药大学 中药制药工程学院,天津 301617
2.天津现代创新中药科技有限公司,天津 300392
陈晨,在读硕士,从事新型制剂技术研究,E-mail:1040272054@qq.com
王海霞,博士,副研究员,从事中药生产过程智能检测及创新药物载体合成研究,E-mail:whxtcm@tjutcm.edu.cn
收稿日期:2021-05-17,
网络出版日期:2021-06-30,
纸质出版日期:2022-04-05
移动端阅览
陈晨,李永圆,王海霞等.制剂技术在提高中药抗菌活性方面的应用及前景分析[J].中国实验方剂学杂志,2022,28(07):247-253.
CHEN Chen,LI Yong-yuan,WANG Hai-xia,et al.Application and Prospect Analysis of Preparation Technology in Improving Antibacterial Activity of Traditional Chinese Medicine[J].Chinese Journal of Experimental Traditional Medical Formulae,2022,28(07):247-253.
陈晨,李永圆,王海霞等.制剂技术在提高中药抗菌活性方面的应用及前景分析[J].中国实验方剂学杂志,2022,28(07):247-253. DOI: 10.13422/j.cnki.syfjx.20211766.
CHEN Chen,LI Yong-yuan,WANG Hai-xia,et al.Application and Prospect Analysis of Preparation Technology in Improving Antibacterial Activity of Traditional Chinese Medicine[J].Chinese Journal of Experimental Traditional Medical Formulae,2022,28(07):247-253. DOI: 10.13422/j.cnki.syfjx.20211766.
致病性细菌感染是临床上的主要疾病之一。抗生素是临床上普遍采用的一种抑制或杀灭细菌、真菌等病原微生物的药物。但随着抗生素的大量使用,耐药性菌株不断出现,抗菌形势日益严峻。中药具有多成分、多靶点、多通路等优势,在对抗细菌感染中逐渐被关注并受到重视。然而,一些抗菌中药也存在溶解度低、稳定性差、生物利用度低等问题,通过制剂技术改善和提高中药抗菌活性是一种有效的解决方案。基于此,笔者拟从单方抗菌中药制剂技术和组合抗菌药物制剂技术两方面入手,介绍了包合、纳米、静电纺丝和3D打印等制剂技术的特点和具体应用效果,并分别就其优势与不足进行阐释,以期为中药抗菌活性的改善与提高提供新思路。
Pathogenic bacterial infection is one of the main clinical symptoms. Antibiotics are widely used in clinical practice to inhibit or kill the bacteria, fungi and other pathogenic microorganisms. However, with the massive use of antibiotics, drug-resistant strains continue to appear that make the antibacterial situation is becoming increasingly severe. Due to the advantages of multiple targets, multiple pathways and multiple components, traditional Chinese medicine (TCM) have gradually attracted more attention and were used in antibacterial treatment. However, some antimicrobial TCM have problems such as low solubility, poor stability, and low bioavailability. Improving and enhancing the antibacterial activity of TCM through preparation technology is one of the effective solutions. Based on this, two aspects of unilateral antibacterial TCM preparation technology and combination antibacterial preparation technology are introduced, including inclusion technology, nanotechnology, electrospinning, 3D printing and others. Distinctive features and specific application effects of these preparation technologies are explained firstly, and then their advantages and disadvantages are compared and analyzed. The review can be a useful reference for improving the antibacterial activity of TCM.
韩飞 , 幸仁汇 , 陈琳琦 , 等 . 中药抗细菌耐药性的研究进展 [J]. 中国中药杂志 , 2016 , 41 ( 5 ): 813 - 817 .
王勇 , 李春 , 仇琪 , 等 . 中药复方多成分多靶点协同增效药理药效评价体系 [J]. 中国科学:生命科学 , 2016 , 46 ( 8 ): 1029 - 1032 .
谭勇 , 谢雁鸣 , 郑永齐 , 等 . 中药联合抗生素治疗感染性疾病的增效减毒机制研究策略 [J]. 中国实验方剂学杂志 , 2019 , 25 ( 6 ): 9 - 14 .
HEMAISWARYA S , KRUTHIVENTI A K , DOBLE M . Synergism between natural products and antibiotics against infectious diseases [J]. Phytomedicine , 2008 , 15 ( 8 ): 639 - 652 .
ZHANG T T , ZHU L F , LI M , et al . Inhalable andrographolide- β -cyclodextrin inclusion complexes for treatment of Staphylococcus aureus pneumonia by regulating immune responses [J]. Mol Pharm , 2017 , 14 ( 5 ): 1718 - 1725 .
KHOSRAVI-DARANI K , KHOOSFI M E , HOSSEINI H . Encapsulation of Zataria multiflora Boiss. essential oil in liposome:antibacterial activity against E. coli O157:H7 in broth media and minced beef [J]. J Food Saf , 2016 , 36 ( 4 ): 515 - 523 .
GONG M , HUANG C L , HUANG Y L , et al . Core-sheath micro/nano fiber membrane with antibacterial and osteogenic dual functions as biomimetic artificial periosteum for bone regeneration applications [J]. Nanomedicine , 2019 , 17 : 124 - 136 .
吕正涛 , 牟子君 . 中药复方制剂的体外抗菌活性研究 [J]. 中医药学报 , 2013 , 41 ( 4 ): 72 - 75 .
XU X W , ZHAO J Z , WANG M N , et al . 3D printed polyvinyl alcohol tablets with multiple release profiles [J]. Sci Rep , 2019 , 9 : 12487 .
ALDRICH A , KUSS M A , DUAN B , et al . 3D bioprinted scaffolds containing viable macrophages and antibiotics promote clearance of Staphylococcus aureus craniotomy-associated biofilm infection [J]. ACS Appl Mater Interfaces , 2019 , 11 ( 13 ): 12298 - 12307 .
赵堉文 , 王海霞 , 别松涛 , 等 . 基于DNA电化学生物传感技术的甘草提取液中大肠杆菌快检方法研究 [J]. 中国中药杂志 , 2018 , 43 ( 6 ): 1209 - 1214 .
WANG H X , ZHAO Y W , BIE S T , et al . Development of an electrochemical biosensor for rapid and effective detection of pathogenic Escherichia coli in licorice extract [J]. Appl Sci , 2019 , 9 : 295 .
WANG H X , ZHAO Y W , LI Z , et al . Development and application of aptamer-based surface-enhanced Raman spectroscopy sensors in quantitative analysis and biotherapy [J]. Sensors (Basel) , 2019 , 19 ( 17 ): 3806 .
刘长青 , 王海霞 , 李正 , 等 . 3D打印技术在中药创新研制与应用方面的研究进展 [J]. 中国实验方剂学杂志 , 2020 , 26 ( 3 ): 236 - 242 .
JANKOWSKI C K , LAMOUROUX C , JIMÉNEZ-ESTRADA M , et al . Factors affecting the formation of 2∶1 host:Guest inclusion complexes of 2-[( R -phenyl)amine]-1,4-naphthalenediones (PAN) in β - and γ -cyclodextrins [J]. Molecules , 2016 , 21 ( 11 ): 1568 .
GUO X , ZHANG L Y , WU S H , et al . Andrographolide interferes quorum sensing to reduce cell damage caused by avian pathogenic Escherichia coli [J]. Vet Microbiol , 174 ( 3/4 ): 496 - 503 .
顾仁勇 , 傅伟昌 , 李佑稷 , 等 . 肉桂精油抑菌及抗氧化作用的研究 [J]. 食品研究与开发 , 2008 , 29 ( 10 ): 29 - 32 .
刘晓艳 , 白卫东 . 肉桂油抑菌及抗氧化作用的研究进展 [J]. 食品与机械 , 2010 , 26 ( 5 ): 169 - 172 .
唐裕芳 , 张妙玲 , 黄白飞 . 肉桂油的提取及其抑菌活性研究 [J]. 天然产物研究与开发 , 2006 , 18 ( 3 ): 432 - 434 .
宋洪涛 , 郭涛 , 赵明宏 , 等 . 肉桂油 β -环糊精包合物的理化性质 [J]. 中国医院药学杂志 , 2003 , 23 ( 1 ): 12 - 14 .
FRANCI G , FALANGA A , GALDIERO S , et al . Silver nanoparticles as potential antibacterial agents [J]. Molecules , 2015 , 20 ( 5 ): 8856 - 8874 .
OLATUNDE O O , BENJAKUL S , VONGKAMJAN K , et al . Liposomal encapsulated ethanolic coconut husk extract:antioxidant and antibacterial properties [J]. J Food Sci , 2019 , 84 ( 12 ): 3664 - 3673 .
CUI H Y , ZHAO C T , LIN L . The specific antibacterial activity of liposome-encapsulated clove oil and its application in tofu [J]. Food Control , 2015 , 56 : 128 - 134 .
PÉREZ-DÍAZ M , ALVARADO-GOMEZ E , MAGAÑA-AQUINO M , et al . Anti-biofilm activity of chitosan gels formulated with silver nanoparticles and their cytotoxic effect on human fibroblasts [J]. Mater Sci Eng C , 2016 , 60 : 317 - 323 .
MA Y H , LIU C Y , QU D , et al . Antibacterial evaluation of sliver nanoparticles synthesized by polysaccharides from Astragalus membranaceus roots [J]. Biomed Pharmacother , 2017 , 89 : 351 - 357 .
SUN W J , QU D , MA Y H , et al . Enhanced stability and antibacterial efficacy of a traditional Chinese medicine-mediated silver nanoparticle delivery system [J]. Int J Nanomedicine , 2014 , 9 : 5491 - 5502 .
LI H H , CHEN Q S , ZHAO J W , et al . Enhancing the antimicrobial activity of natural extraction using the synthetic ultrasmall metal nanoparticles [J]. Sci Rep , 2015 , 5 : 11033 .
JIA H R , ZHU Y X , DUAN Q Y , et al . Nanomaterials meet zebrafish:toxicity evaluation and drug delivery applications [J]. J Control Release , 2019 , 311/312 : 301 - 318 .
WANG B , FENG W Y , ZHAO Y L , et al . Metallomics insights for in vivo studies of metal based nanomaterials [J]. Metallomics , 2013 , 5 ( 7 ): 793 - 803 .
GAJJAR P , PETTEE B , BRITT D W , et al . Antimicrobial activities of commercial nanoparticles against an environmental soil microbe, Pseudomonas putida KT2440 [J]. J Biol Eng , 2009 , 3 : 9 .
IVANOVA K , IVANOVA A , RAMON E , et al . Antibody-enabled antimicrobial nanocapsules for selective elimination of Staphylococcus aureus [J]. ACS Appl Mater Interfaces , 2020 , 12 ( 32 ): 35918 - 35927 .
GAO M Q , LONG X , DU J , et al . Enhanced curcumin solubility and antibacterial activity by encapsulation in PLGA oily core nanocapsules [J]. Food Funct , 2020 , 11 ( 1 ): 448 - 455 .
TIAN X H , WANG P L , LI T , et al . Self-assembled natural phytochemicals for synergistically antibacterial application from the enlightenment of traditional Chinese medicine combination [J]. Acta Pharm Sin B , 2020 , 10 ( 9 ): 1784 - 1795 .
HUANG X M , WANG P L , LI T , et al . Self-assemblies based on traditional medicine berberine and cinnamic acid for adhesion-induced inhibition multidrug-resistant Staphylococcus aureus [J]. ACS Appl Mater Interfaces , 2020 , 12 ( 1 ): 227 - 237 .
LI T , WANG P L , GUO W B , et al . Natural berberine-based chinese herb medicine assembled nanostructures with modified antibacterial application [J]. ACS Nano , 2019 , 13 ( 6 ): 6770 - 6781 .
RAVIKRISHNAN A , OZDEMIR T , BAH M , et al . Regulation of epithelial-to-mesenchymal transition using biomimetic fibrous scaffolds [J]. ACS Appl Mater Interfaces , 2016 , 8 ( 28 ): 17915 - 17926 .
GREINER A , WENDORFF J H . Electrospinning:a fascinating method for the preparation of ultrathin fibers [J]. Angew Chem Int Ed Engl , 2007 , 46 ( 30 ): 5670 - 5703 .
DONG W H , LIU J X , MOU X J , et al . Performance of polyvinyl pyrrolidone-isatis root antibacterial wound dressings produced in situ by handheld electrospinner [J]. Colloids Surf B , 2020 , 188 : 110766 .
SAMADIAN H , ZAMIRI S , EHTERAMI A , et al . Electrospun cellulose acetate/gelatin nanofibrous wound dressing containing berberine for diabetic foot ulcer healing: in vitro and in vivo studies [J]. Sci Rep , 2020 , 10 ( 1 ): 8312 .
HE Y , ZHAO W W , DONG Z X , et al . A biodegradable antibacterial alginate/carboxymethyl chitosan/Kangfuxin sponges for promoting blood coagulation and full-thickness wound healing [J]. Int J Biol Macromol , 2021 , 167 : 182 - 192 .
YANG L , HAN Z , CHEN C H , et al . Novel probiotic-bound oxidized Bletilla striata polysaccharide-chitosan composite hydrogel [J]. Mater Sci Eng C , 2020 , 117 : 111265 .
JIA D , DOU Y H , LI Z W , et al . Design,synthesis and evaluation of a baicalin and berberine hybrid compound as therapeutic agent for ulcerative colitis [J]. Bioorg Med Chem , 2020 , 28 ( 20 ): 115697 .
TAMJID E , BOHLOULI M , MOHAMMADI S , et al . Sustainable drug release from highly porous and architecturally engineered composite scaffolds prepared by 3D printing [J]. J Biomed Mater Res A , 2020 , 108 ( 6 ): 1426 - 1438 .
BAI J F , WANG H , GAO W , et al . Melt electrohydrodynamic 3D printed poly ( ε -caprolactone)/polyethylene glycol/roxithromycin scaffold as a potential anti-infective implant in bone repair [J]. Int J Pharm , 2019 , 576 : 118941 .
ROBLES-MARTINEZ P , XU X Y , TRENFIELD S J , et al . 3D Printing of a multi-layered polypill containing six drugs using a novel stereolithographic method [J]. Pharmaceutics , 2019 , 11 ( 6 ): 274 .
0
浏览量
20
下载量
1
CSCD
关联资源
相关文章
相关作者
相关机构
京公网安备11010802024621