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1.陕西国际商贸学院,陕西 咸阳 712046
2.陕西步长制药有限公司,西安 710075
3.中国中医科学院 中药资源中心,北京 100700
马存德,副主任药师,从事中药资源调查与规范化种植研究,Tel:029-88318318-6762,E-mail:mcd1016@126.com
詹志来,博士,研究员,从事中药品质评价、本草考证、中药标准化研究,Tel:010-64087649,E-mail:zzlzhongyi@163.com
纸质出版日期:2022-05-20,
网络出版日期:2021-09-16,
收稿日期:2021-07-03,
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马存德,常晖,杨祎辰等.经典名方中地龙的本草考证[J].中国实验方剂学杂志,2022,28(10):184-192.
MA Cun-de,CHANG Hui,YANG Yi-chen,et al.Herbal Textual Research on Pheretima in Famous Classical Formulas[J].Chinese Journal of Experimental Traditional Medical Formulae,2022,28(10):184-192.
马存德,常晖,杨祎辰等.经典名方中地龙的本草考证[J].中国实验方剂学杂志,2022,28(10):184-192. DOI: 10.13422/j.cnki.syfjx.20211867.
MA Cun-de,CHANG Hui,YANG Yi-chen,et al.Herbal Textual Research on Pheretima in Famous Classical Formulas[J].Chinese Journal of Experimental Traditional Medical Formulae,2022,28(10):184-192. DOI: 10.13422/j.cnki.syfjx.20211867.
通过查阅历代本草及医书典籍,结合现代文献资料、实地调查,笔者拟对经典名方中地龙药材的名称、基原、产地、品质、采收加工等方面进行考证,梳理古今药用地龙基原关系,为相关经典名方的开发与利用提供参考依据。经考证可知,地龙别名众多,本草类书籍以“蚯蚓”或“白颈蚯蚓”为正名。宋代及之后的方剂类书籍中处方名多用“地龙”之名。民国从《药物出产辨》开始,以“地龙”为正名。地龙在我国资源分布较广,全国各地均有出产,多为野生。根据古代地龙以“白颈蚯蚓”“颈白身紫”“大条”为入药原则,结合历史渊源、产地及易获取等方面确定,古代至今使用的地龙以参环毛蚓
Pheretima aspergillum
为主流,兼有其他多种蚯蚓作地龙入药。《中华人民共和国药典》(以下简称《中国药典》)根据历史渊源和产地采收实际情况,自1995年版始,统一了地龙的基原,将参环毛蚓
P. aspergillum
加工的药材称为“广地龙”;将通俗环毛蚓
P. vulgaris
、威廉环毛蚓
P. guillelmi
和栉盲环毛蚓
P. pectinifera
加工的药材称为“沪地龙”。自此,之后出版的各本草书籍均与当时实行的《中国药典》为准。“广地龙”的道地产区为广东、广西等地;“沪地龙”的主产地为江苏、上海、浙江、安徽等地。且以广东、广西等地所产的“广地龙”品质最佳。采收后,去除泥土和内脏,洗净,干燥。临床切段入药,或依方炮制入药。古代地龙以“白颈蚯蚓”“颈白身紫”“大条”为主要质量评判标准,根据历史渊源,参环毛蚓
P. aspergillum
是地龙的主流基原,其品质较其他种类优良。因此建议身痛逐瘀汤中的地龙使用产于广东、广西等地的参环毛蚓
P. aspergillum
。采后及时剖开腹部,除去内脏和泥沙,洗净,干燥。
By consulting ancient herbal medicines and medical books, combined with modern documents and field investigations, the textual research of Pheretima has been conducted to verify the name, origin, producing area, quality, harvesting and processing changes, and sort out the relationship of origin between ancient and modern times, so as to provide reference and basis for the development and utilization of the related famous classical formulas. Through textual research, it is known that there are many aliases for Pheretima, the rectification of name was "Qiuyin" or "Baijing Qiuyin" in materia medica books. In the Song dynasty and later prescription books, the prescription name is mostly Dilong. From the beginning of
Yaowu Chuchanbian
(《药物出产辨》), Dilong was used as the rectification of name. It is widely distributed in our country, which is produced all over the country and mostly wild. According to ancient Pheretima with "Baijing Dilong", "Jingbai Shenzi" and "Datiao" as the principles of medicine, combined with historical origin, producing area and easy access, it is confirmed that Pheretima used in ancient times to the present is mainly
Pheretima aspergillum
, and it also has many other Qiuyin as Pheretima for medicinal purposes.
Chinese Pharmacopoeia
has unified the origin of the Pheretima since the 1995 edition based on historical origins and actual harvesting conditions. The medicinal material processed by
P. aspergillum
was called Guangdilong, and the medicinal materials processed by
P. vulgaris
,
P. guillelmi
and
P. pectinifera
were called Hudilong. Since then, all the herbal books published in the future are in line with
Chinese Pharmacopoeia
that was implemented at that time. The authentic production areas of Guangdilong are Guangdong and Guangxi, and the authentic production areas of Hudilong is Jiangsu, Shanghai, Zhejiang and Anhui. The Guangdilong produced in Guangdong and Guangxi has the best quality. After harvesting, remove the soil and offal, wash and dry. Clinically cut into sections for medicine, or prepare medicine according to prescription. The Pheretima in ancient used "Baijing Dilong", "Jingbai Shenzi" and "Datiao" as the mainstream quality evaluation standards. According to historical origins,
P. aspergillum
should be the main source of Pheretima, and its quality is better than other species. Therefore, it is recommended that Pheretima in Shentong Zhuyutang use
P. aspergillum
, which is produced in Guangdong, Guangxi and other places. After harvest, the abdomen was opened in time to remove the viscera and sediment, washed and dried.
经典名方地龙本草考证基原产地品质评价采收加工
famous classical formulasPheretimaherbal textual researchoriginproducing areaquality evaluationharvesting and processing
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