Objective

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To explore the dynamic evolution law of syndrome elements in different stages of chronic obstructive pulmonary disease （COPD）.

Method

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The clinical questionnaire of COPD was formulated，and the clinical data of 303 patients with COPD in the acute exacerbation stage，risk window stage，and stable stage in the First Affiliated Hospital of Henan University of Chinese Medicine from June 2019 to December 2020 were dynamically collected. The Clinical Investigation and Research Database on the Evolution of Syndrome Elements of COPD was established，with syndrome elements as nodes and complex relationships between syndrome elements and syndrome elements in different stages as edges. With the help of Pycharm （JetBrains PyCharm Edition 2018.2.3） development tool，python programming was used to preprocess the data and perform complex network modeling. The complex network of different stages of COPD was constructed to analyze the evolution law of syndrome factors in different stages.

Result

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A total of 303 patients with COPD were included and finished. Eleven syndrome elements were extracted in the acute exacerbation stage，10 syndrome elements were extracted in the risk window stage，and 8 syndrome elements were extracted in the stable stage. According to the complex network centrality and edge weight of disease syndrome elements，it was found that the core nodes of disease syndrome elements in the network from the acute exacerbation stage to the stable stage were phlegm，heat，and Qi deficiency，Qi deficiency，phlegm，and dampness，and Qi deficiency，Yin deficiency，and blood stasis.

Conclusion

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From the acute exacerbation stage to the stable stage，the disease syndrome elements change from excess to deficiency，and phlegm heat gradually changes into phlegm dampness，and gradually weakens or disappears. Qi deficiency runs through the whole process of the disease and turns into both qi and yin deficiency with blood stasis.