Wumeiwan are recorded in the Jueyin chapter of

Treatise on Cold Damage and Miscellaneous Diseases

（《伤寒杂病论》）， and many doctors in the past dynasties believed that they had the effects of calming intestinal ascarid by warming Zang organs. The clinical application was limited. Since KE Qin， a doctor in the Qing dynasty， proposed that Wumeiwan were the primary prescription against Jueyin diseases， Wumeiwan have been valued by doctors， and their clinical application has also been expanded. The syndrome indicated for Wumeiwan is attributed， not only to the ascarid internal harassment， but to the abnormal Qi movement of wind and wood in Jueyin and the dysfunction of Yin and Yang. According to the functions of six meridians based on the theory of "open-close axis" in

Huangdi's Internal Classic

（《黄帝内经》） and the original texts of

Treatise on Cold Damage and Miscellaneous Diseases

， Yinshu refers to Jueyin. Wumeiwan， the primary prescription against Jueyin diseases， have the function of connecting Yin and Yang， and they can treat diseases caused by Qi disturbance of Jueyin and cold and heat in complexity. Sharing the same resource， the

Secrets for Auxiliary Cultivation Life

：

The Essential Method of Using Herbal Medicine for the Differential Treatment of the Five Zang Organs

（《辅行诀五脏用药法要》） and

Treatise on Cold Damage and Miscellaneous Diseases

both consult

Models of the Classic of Decoction

（《汤液经方》）. The formulation rules of tonic/purgative and collapse-saving prescriptions in

Secrets for Auxiliary Cultivation Life

follow the recorded "Tang Ye Jing Fa Tu" （an image revealing the compatibility principles of Chinese herbal drugs） and are closely related to the five elements theory. By exploring the formulation rules in "Tang Ye Jing Fa Tu" and the five elements of drugs， this study analyzed Wumeiwan and proved that Wumeiwan mainly acted on the liver， spleen， and heart. According to the Five Zang-organs Storing Spirit theory from

Huangdi's Internal Classic

， the above three organs are closely related to emotional adjustment. Therefore， the treatment of emotional disorders caused by qi disturbance of Jueyin and cold and heat in complexity with Wumeiwan is supported by evidence. At the end of this article， the reports on the treatment of emotional disorders with Wumeiwan in recent years were listed and reviewed. This article provides new ideas for the clinical application of Wumeiwan in the treatment of emotional disorders and expands the application range.