芪附汤对阿霉素心脏毒性损伤的保护作用及其抗氧化机制

于彩娜; 范颖; 林庶茹

doi:CNKI:11-3495/R.20110303.1348.006

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芪附汤对阿霉素心脏毒性损伤的保护作用及其抗氧化机制

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- 芪附汤对阿霉素心脏毒性损伤的保护作用及其抗氧化机制
- Protective Effect and Antioxidant Mechanism of Qifu Decoction on Adriamycin-induced Cardiac Injury
- 中国实验方剂学杂志 2011年17卷第8期页码：193-196
- 作者机构：
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- 基金信息：
  
  辽宁省教育厅高等学校创新团队项目(2007T117)
- DOI：CNKI:11-3495/R.20110303.1348.006
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- 纸质出版日期：2011
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于彩娜, 范颖, 林庶茹. 芪附汤对阿霉素心脏毒性损伤的保护作用及其抗氧化机制[J]. 中国实验方剂学杂志, 2011,17(8):193-196.

YU Cai-na, FAN Ying, LIN Shu-ru. Protective Effect and Antioxidant Mechanism of Qifu Decoction on Adriamycin-induced Cardiac Injury[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(8): 193-196.
于彩娜, 范颖, 林庶茹. 芪附汤对阿霉素心脏毒性损伤的保护作用及其抗氧化机制[J]. 中国实验方剂学杂志, 2011,17(8):193-196. DOI： CNKI:11-3495/R.20110303.1348.006.

YU Cai-na, FAN Ying, LIN Shu-ru. Protective Effect and Antioxidant Mechanism of Qifu Decoction on Adriamycin-induced Cardiac Injury[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(8): 193-196. DOI： CNKI:11-3495/R.20110303.1348.006.

摘要

目的: 观察芪附汤对阿霉素心脏毒性损伤模型大鼠心脏功能的影响

并初步探讨其作用机制。方法: 采用心电图仪测定心脏功能的相关参数

采用化学比色法检测心肌细胞超氧化物歧化酶(superoxide dismutase

SOD) 和谷胱甘肽过氧化物酶(glutathione peroxidase

GSH-Px)活性及脂质过氧化产物丙二醛(malondialdehyde

MDA)含量。结果: 与正常组相比较

模型组大鼠心率显著减慢

QRS波群电压明显降低

Q-T间期明显延长

均有统计学意义(P<0.05)

个别出现心律失常;与模型组相比较

芪附汤组、中药对照组心率增加

QRS波群电压和明显增高

Q-T间期显著缩短

均有统计学意义(P<0.05)。与正常组相比较

模型组、芪附汤组、中药对照组心肌细胞SOD和GSH-Px活性减弱

MDA含量上升

均有统计学意义(P<0.05);与模型组相比较

芪附汤组、中药对照组心肌细胞SOD和GSH-Px活性增强

MDA含量下降

均有统计学意义(P<0.05)。结论: 芪附汤对阿霉素诱导的大鼠心脏毒性损伤具有保护作用

作用机制与其抗氧化应激有关。

Abstract

Objective: To investigate the effect of Qifu Decoction on heart function of adriamycin-induced cardiac injury in a rat model

and to discuss the mechanism. Method: Heart function was measured by ECG instrument

the activities of superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px) were detected

and the content of lipid peroxidation product malondialdehyde(MDA) were checked by chemical colorimetric method. Result: Compared with the normal group

the heart rate of the rats in the model group was slowed down

the sum of QRS voltage decreased

Q-T interval extended

all with statistically significance(P<0.05). Arrhythmia appeared in a few individuals. Compared with the model group

the heart rate of the rats in Qifu Decoction group and Chinese herb control group was speeded up

the sum of QRS voltage increased

Q-T interval shortened

all with statistically significance(P<0.05). Compared with the normal group

the activities of SOD and GSH-Px were weakened

and the content of MDA increased in the model group

Qifu Decoction group and Chinese herb control group

all with statistically significance(P<0.05). Compared with the model group

the activities of SOD and GSH-Px were strengthened

and the content of MDA decreased in Qifu Decoction group and Chinese herb control group

all with statistically significance(P<0.05). Conclusion: Qifu Decoction can protect the heart from adriamycin in the rat model. Its mechanism may be related with antioxidant stress.

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