Objective: Through observing the treatment of geriatric hypertension by Shuxuetong injection on the activity of PRA

the content of AngⅡ

ET

NO

to investigate the mechanism of Shuxuetong on antihypertension. Method: All of the hypertension patients were randomized into treating group (n=40)and control group (n=36).The two groups were all treated with Captopril.The treating group was given Shuxuetong injection additionally.The total course was 14 days.We observed the change of PRA

ET

AngⅡ

NO and the other biochemical data before and after the treatment. Result: The level of ET and AngⅡwas descending

and the level of PRA

NO was ascending in the treating group(P<0.01).There was a significant difference compared with the control group for the level of ET

NO

PRA(P<0.05).The difference of the level of AngⅡwas insignificant.The hemorheological parameters and lipids in the treating group were improved obviously

and the difference was significant compared with the control group(P<0.01). Conclusion: Shuxuetong injection could improve renin-angiotensin system for geriatric hypertension

raise the level of NO

lower the content of ET and AngⅡ

improve the hemorheological parameters and the function of lipids and endothelium

lower blood pressure effectively.