Objective: To observe the protective effect of Lixin granule on the neuroendocrine and inflammation of rats with adriamycin-induced heart failure. Method :Sixty adult male Wistar rats were divided into 5 groups:normal control group(NC)

adriamycin(ADR)group

L- Lixin granule group(20 g ·kg-1)

H- Lixin granule group(40 g ·kg-1)

captopril group(16 mg ·kg-1 ). Then ADR of 4 mg ·kg-1 was given intraperitoneally once in every 5 days(total 3 times)to copy the model of heart failure. The biological signal collecting system was used to record and analyze the LVSP of the rats. The pathological changes in the cardiomyocytes were observed. Real time PCR was used to record and analyze the neuroendocrine and inflammation of rats. Immunohistochemistry staining was used to detect TIMP-1. Result: As compared with NC group

the LVSP of the ADR group was significantly lower(P <0.05)

but those of the H- Lixin granule group were markedly higher than those of the ADR group(P <0.01). HE staining showed that the myocardial tissue in CHF group was injured

presenting in cardiomyopthy-like changes;in NC group

muscle fiber was arranged regularly with no injury muscle fibers;in the treatment group

Lixin granule partially normalized contractile function. Real time PCR and Serological detection staining showed that the neuroendocrine factors(ANP

BNP

ET)and inflammatory factor(TNF-α)of rats were increased by ADR

and those of the H- Lixin granule group were markedly lower compared with ADR group(P<0.01). Conclusion: H- Lixin granule group treatment can relieve the neuroendocrine and inflammation induced by ADR in myocardium

and also obviously improve the cardiac contractility of heart failure rats.