Objective: To observe the effect of Zhiwei Fuwei concentrated pill(FW)on gastric secretory function and histomorphology of gastric mucosa in chronic atrophic gastritis (CAG) model rats

and to investigate the mechanism of FW in prevention and treatment of CAG. Method :An experimental CAG model was established by comprehensive factors(including alternative ingestion with 30% ethanol and 2% sodium salicylate mixed solution and 10 mmol ·L-1 sodium deoxycholate

0.05% ammonia by drinking daily

combining with active immunization method

followed by either hunger or gorge)in Wistar rats.Three doses of FW were used(1.67

0.84

0.42 g ·kg-1 ig

35 d)as treatment.The pepsin activity was tested by colorimetry

the content of gastric secretion

gastric acid pH and total acid of gastric were determined

the histomorphology of gastric mucosa was observed. Result: FW could improve the general conditions significantly for CAG rats. The high dosage of FW could increase gastric secretion and total acid of gastric(P<0.05).All dosage of FW could promote pepsin activity(P<0.01). There was a positive correlation between the effect and dosage. It had good improving effect on pathologic morphology of gastric mucosa. Conclusion: FW can improve gastric secretory function and histomorphology of gastric mucosa in CAG model rats.