Objective: To study the effect of Achyranthis Bidentatae Radix and achyranthis bidentatae polysaccharides (ABPS) on the mice’s immune function

and investigate the consistency of both effects. Method: Kunming mice were divided into 5 groups: blank control group

immunosuppression model group

decoction group of Achyranthis Bidentatae Radix

ABPS group and mushroom polysaccharides group. The immunosuppression model of mouse was established with injecting cyclophosphamide abdominally. The effects of the decoction of Achyranthes Bidentatae Radix and ABPS on thymus weight

spleen weight

percentage of phagocytosis

phagocytic index

hemolysin

hemolysis of plaque and lymphocyte transformation rate were compared. Result: The decoction of Achyranthes Bidentatae Radix and ABPS both could improve model mice spleen weight

phagocytic percentage and phagocytic index

promote the formation of hemolysin and hemolytic plaque

and increase the rate of lymphocyte transformation. Compared with model group

both of them could improve immune indexes of the immunosuppressed mouse

and there was significant difference (P<0.01 or P<0.05). With the dosage in this study

the effect of the decoction of herbal pieces at 20 g·kg-1 was equal to that of ABPS at 0.5 g·kg-1 for improving immune function. Conclusion: ABPS is the main effective composition of Achyranthes Bidentata Radix for reinforcing immune function.