Objective: To investigate the mechanism of nourishing kidney and reducing urine by investigating the regulative action of Suoquanwan to HPA. Method: The rat model of kidney deficiency and diuresis was established by adenine (150 mg·kg-1

ig 4 weeks)

From the second week after the model establishment

the treatments were ig given

including Suoquanwan (1.170

0.585

0.293 g·kg-1)

Jinsuo Gujin Wan (0.968 g·kg-1). The contents of CRH

ACTH

cAMP in blood in model group

Suoquanwan group

Jinsuo Gujin Wan group and controll group were determined with ELISA and RIA technology

and also the hypophysis index and adrenal gland index were calculated. Result: Compared with the model group

Suoquanwan could remarkedly increase the contents of CRH

ACTH

cAMP in blood in rats with kidney deficiency and diuresis and improve the hypophysis exponent and adrenal gland exponent. Conclusion: Suoquanwan can enhance the action of body adjusting water metabolize by coordinating the function of HPA.The results of the experiment expound the mechanism of nourishing the kidney and reducing urine of Souquan Wan from the point of view of endocrine.