Objective: To observe effect of Huangqi Gegen decoction on diabetes mellitus and insulin resistance experimentally with models of mouse and rat. Method: Diabetic mouse model was induced by intraperitoneal injection of streptozotocin (STZ

160 mg·kg-1)

insulin resistance mouse model was induced by hypodermical injection of hydrocortisone sodium succinate. Type 2 diabetes model with insulin resistance (T2DM-IR) of rat was induced by intraperitoneal injection of lower dosage of STZ (30 mg·kg-1) with high fat diet. The effects of Huangqi Gegen decoction on glucose or lipid metabolism and insulin IR were investigated with these models. Result: Huangqi Gegen decoction obviously improved fasting blood glucose and glucose tolerance of diabetic mice induced by STZ

increased insulin sensitivity in insulin resistance mice

also it showed significant lower fasting blood glucose

improved sugar tolerance

lowered serum hyperinsulinism

increased insulin tolerance

improved ISI and lowered HOMA-IR index

and regulated blood fat

down regulated serum free fatty acids in T2DM-IR rats. Conclusion: Huangqi Gegen decoction can improve glycolipid metabolism

increase insulin sensitivity to cure T2DM-IR.