Objective: To investigate the effect of traditional chinese medicine Kuiyangping on gastric mucosal blood flow(GMBF) and the serum concentration of endothelin-1(ET-1) and nitric oxide(NO) rats with in acetic acid-induced gastric ulcer(GU). Method: The ulcer model in rats was prepared with Okabe’s method with some modifications. The rats were randomly divided into 6 groups:normal control group

model group

low

middle and high-dose of Kuiyangping groups(1.4

2.8

5.6 g ·kg-1

ig) and ranitidine hydrochloride group(2.83×10-2g ·kg -1

ig). After the 14 days treatment

GMBF of the mucosa around the GU were measured by the LDF100C of MP150 BIOPAC System. We also determined the serum concentration of ET-1 by ELISA

and determined the serum concentration of NO by nitrate reductase one step method. Result: Compared with model group

GMBF was higher(P<0.05)

the serum concentration of ET-1 was lower(P<0.01) and NO was higher(P<0.05) significantly in high-dose of Kuiyangping group. Compared with ranitidine hydrochloride group

GMBF was higher(P<0.05)

the serum concentration of ET-1 was lower(P<0.01) and NO was higher(P<0.05) significantly in high-dose of Kuiyangping group. Conclusion: Kuiyangping could promote the synthesis and release of NO

however

NO could inhibit the release of ET-1.So Kuiyangping could increase the GMBF. Which may be one of the mechanisms of Kuiyangping to promote the healing of gastric ulceration and improve quality of ulcer healing.