Objective: To investigate strengthening yang action of Yangxin Tiaogan Yishen decoction and its possible mechanism. Method: On the 8th days after making castrated model rats by operation

we respectively fed NS

Yangxin Tiaogan Yishen decoction(50

25 g ·kg-1)

Nanbao mixed liquid(0.56 g ·kg-1) into the stomaches of the different groups of male rats for 21 days. Afterwards

the weight of prepputial gland

sperm bladder-prostate

anus levator muscle

content of testosterone(T) and cortisol(F) in blood serum and nitric oxide(NO) content of endothelium cell of penial corpus cavernosum were observed. Result: The indexes of prepputial gland

sperm bladder-prostate

anus levator muscle

and content of T

F and NO were increased

these items of Yangxin Tiaogan Yishen decoction group were higher than these of the model group (P<0.05). The deta in Yangxin Tiaogan Yishen decoction with high dose group were especially remarkable(P<0.05). Conclusion: Yangxin Tiaogan Yishen decoction can adjust lower thalamus-hypophysis-sexual gland axis and adrenal function

and it can strengthen yang action.