Objective: To explore the protective effect and mechanism of Qiju Dihuang Wan (QJDH) on kidney in diabetic rats. Method: Rat diabetic model was set up by intraperitoneal injection of streptozotocin. Thirty-two SD rats were randomly divided into normal group

model group

QJDH high and low dose group (2

1 g·kg-1)

and each group contained eight rats. The daily treatments were started at 72 h after model establishment

and lasted for 4 weeks.The general state of rats was observed. Blood sugar

kindey weight/body weight index

24 h urine protein

serum creatinine(SCr)

blood urea nitrogen(BUN)

malondialdehyde (MDA)

superoxide dismutase (SOD) were measured by different methods. Result: QJDH was able to obviously ameliorate the general state of diabetic rats

reduce 24 h urine protein

SCr and BUN content

decrease MDA content and increase SOD activity in kindey tissue. Conclusion: QJDH can relieve the oxidative stress of kindey tissue

and lighten kindey injury induced by diabetes mellitus in diabetic rats.