Objective: To explore the forming mechanism of gastric ulcer model induced by indomethacin combined with cold or heat syndrome. And to observe the basic mechanism of action and objective regularity of 'formula-syndrome corresponding’ of cold or heat formula on gastric ulcer model combined with cold or heat syndrome. Method: One hundred and forty Wistar rats were divided into blank group

disease model group

disease combined with syndrome model group

syndrome model group randomly. Adopting cold (ice water

NaOH)or heat (8%dry pepper powder with ethanol liquid)factors

ig 7 d continuously to establish the stomach cold or heat syndrome models. Then ig cold prescription(Dahuang Huanglian Xiexin decoction 1.8 g·kg-1)

or heat prescription(Lizhong pill 3.6 g·kg-1)

was given for 4 d continuously. After the last ig

fasting 30 h

then ip indomethacin was given to establish the gastric ulcer model combined with cold or heat syndrome

so called 'disease combined with syndrome’model.Using radiation immune analysis or euzymelinked immunosorbent assay to detect the contents of gastrin (GAS)

motilin(MOT) in serum. Result: Compared to the blank group

the content of GAS in serum was increased remarkably in each model groups (P<0.05 or P<0.01). Excepting the cold syndrome group

compared to the blank group

the content of MOT in serum was increased remarkably in each model groups. (P<0.01). And the contents of MOT in serum increase remarkably in the heat factor groups. Dahuang Huanglian Xiexin Decoction or Lizhong Pill could respectively decrease the contents of GAS

MOT in serum of heat-ulcer group or cold-ulcer group obviously (P<0.05 or P<0.01). Conclusion: On the basis of the theory of 'formula-syndrome corresponding’

duplication of "disease-syndrome combination" model

i.e. gastric ulcer model combined with cold or heat syndrome

appears to be feasible. The therapeutic action of Dahuang Huanglian Xiexin decoction on heat-gastric ulcer

or Lizhong Pill on cold-gastric ulcer both is likely achieved by decreasing the contents of GAS

MOT in serum.