Objective: To investigate the effect and its mechanism of Kanli granule on heart failure hemodynamics in chronic heart failure by partial coarctation of abdominal aorta in rats. Method: The chronic heart failure (CHF) model was induced by partial coarctation of abdominal aorta in rats. The CHF rats were feeded with Kanli granule(unprepaired herbal medicine 12 g·kg-1·d-1)for 24 weeks

and the captopril group(3.375 medicine given Kanli granule 12 g·kg-1·d-1)for 24 weeks. After 24 weeks

cardiac hemodynamics parameters

left ventricular mass index (LVMI)

Cardiac mass index (CMI)

left ventricular systolic pressure (LVSP)

left ventricular diastolic pressure (LVDP)

left ventricular end-diastolic pressure(LVEDP)

collagen volume fraction(CVF)

collagenⅠ/Ⅲ ratio were measured pathologically. Myocardial cell and interstitial collagen were observed by HE and VG stain. Result: Kanli granule availably improved cardiac hemodynamics parameters including LVSP

LVEDP

±LVdp/dtmax

decreased CVF and CMI (P<0.05) including LVMI(P<0.01)

meanwhile increased Ratio of type I/1I)(P<0.05). Conclusion: Kanli granule can availably improved cardiac hemodynamics parameters of rats with CHF

regulate over-degradation of myocardial collagen and prevent ventricle expanding which are related to relieving the myocardial extracellular matrix remodeling of CHF.