Objective :To study the anti-inflammatory and antipyretic effect and mechanism of the ethanol extracts from Musca domestica larvae(MDE) on febrile rats. Method :The rats fever model were made by dry yeast. Saline group was given equal volumes saline (ig); Model group was given equal volumes saline (ig)+ sc 15% dry yeast 20 mL·kg-1 of subcutaneous injection; Treatment group: MDE(1

0.5

0.25 g·kg-1)

ig qd for 7 d

Rectum temperature (ΔT/ ℃)was measured and hypothalamus proataglandin E2(PGE2) and adenosine cyclophosphate(cAMP) were detected by RIA. Result :1

0.5

0.25 g·kg-1MDE had antipyretic effect on febrile rats and could reduce the content of PGE2 and cAMP·kg-1) (126.86±24.89) ng·g-1

(9.72±1.11) nmol·g-1]

·kg-1) (180.12±34.58) ng·g-1

(10.05±0.26) nmol·g-1]

·kg-1)(203.54±30.46) ng·g-1

(10.79±0.57) nmol·g-1]

campared to the control(253.70±43.96) ng·g-1

( 12.15±3.11) nmol·g-1)(P<0.01

P<0.05). Conclusion :The results indicate that ethanol extracts from M. domestica larvae has anti-inflammatory and antipyretic effect

the mechanism may be related to reducing PGE2 and cAMP.