Objective :To investigate the effects of Aucklandia lappa

bran-roasted products and the two active monomer on gastrointestinal motility in mice. Method : The normal mice were randomly divided into nine groups in average: blank control group

mosapride control group

Jianwei Xiaoshi pian control group

the raw and bran-roasted A.lappa group (5

10

20 g·kg-1 ).The blank control group was given distilled water and the other groups were given appropriate extracts by intragastic admistration once a day for two weeks. The mice with reserpine induced were divided into fifteen groups:blank control group

model control group

Mosapride control group

the raw and bran-roasted A.lappa group (5

10

20 g·kg-1 )

costunolide group (1.25

2.5

5.0 mg·kg-1)and dehydrocostuslactone group (2.5

5.0

10.0 mg·kg-1). The blank control group were injected distilled water subcutaneously

the other groups were given reserpine by subcutaneous injection. The blank and model control groups were given distilled water. mosapride control group

the raw and bran-roasted A. lappa group (5

10

20 g·kg-1 )were given appropriate extracts by intragastic admistration (20 mL·kg-1)

costunolide and dehydrocostuslactone groups were injected(5 mL·kg-1) intraperitoneally for two weeks. Charcoal as a marker was orally administered to determine the propulsive function of small intestine and gastric emptying. Result : The results of gastric emptying and intestine propulsion experiments in normal mice suggested that the effects of the raw and bran-roasted A. lappa on gastric emptying is not significance. The raw materials (10

20 g·kg-1 ) promoted the intestine propulsion(P<0.05). The bran-roasted products(5

10 g·kg-1)

costunolide and dehydrocostuslactone had significance effects on gastric emptying for the reserpine treated mice

the raw materials and costunolide(5 mg·kg-1)promoted the intestine propulsion for the reserpine treated mice(P<0.05). Conclusion : The raw A. lappa has effective in the promoting the circulation of qiand is benefit for spleen deficiency

the active conponent costunolide plays an important role especially.