Objective :To investigate the changes of chemical compositions before and after the compatibility of Ramulus Cinnamomi and Rhizoma Zingiberis in order to explore the effective material base through.comparative study on supercritical fluid extraction and steam distillation in extracting chemical constituents and relative contents of the volatile oil from the compatibility of Ramulus Cinnamomi and Rhizoma Zingiberis. Method: Using supercritical fluid extraction and steam distillation

chemicals in Ramulus Cinnamomi

Rhizoma Zingiberis and herbal pair Ramulus Cinnamomi-Rhizoma Zingiberis were extracted. The chemicals were indenified before and after mixing the medicines by using GC-MS. The changes in the mixture were summerized and recorded. Result: The mass percentage of extractions from Ramulus Cinnamomi

Rhizoma Zingiberis

and the herbal pair by SFE-CO2 were 0.69%

3.66%

1.82%

respectively

and 44

57

and 65 chemical components were identified from the three extractions. The identified components were 84.22%

91.25%

and 90.13% of the extractions

respectively. Though steam distillation

the mass percentage of collected volatile chemicals were 0.25%

1.75%

1.05% from Ramulus Cinnamomi

Rhizoma Zingiberis

and the herbal pair. 19

50

57 chemical components were identified. The identified components were 85.35%

93.47%

and 93.11% of the extractions

respectively. Conclusion : The compatibility of Ramulus Cinnamomi and Rhizoma Zingiberis can promote dissolution of the chemicals in the medicines

and the compatibility is not in simple mixture of the components

and extraction efficiency by SFE-CO2 is higher than that by steam distillation.