Study Nogo-A and its receptor NgR (Nogo receptor) in promoting nerve regeneration and the intervention of traditional Chinese medicine(TCM)

to find out the progress of TCM in repairing impaired central nervous system(CNS) that related to drug targets of Nogo-A and NgR. Based on the understanding of the expression and function of Nogo-A

the Nogo-A monoclonal antibody and the NgR antagonist

understanding more about the mechanism of repairing damaged CNS had an important clinic significance for the drug in treating neurite outgrowth inhibition following CNS injury. TCM can induce CNS produced beneficial micro-environment to promote nerve regeneration. The intervention of TCM can inhibit the expression of Nogo-A and NgR that can inhibit the occurrence of nervous. But Nogo-A in the research of the treatment of brain damage is still in the basic stage

reports on using TCM (Suifukang

Shouwuxianhai tablet

Sanqi Panax Notoginseng

Panaxtriol saponins

Xiaoyao powder

Buyang Huanwu decoction

Zuogui pill

and Yougui pill

etc.)to regulate the expression of Nogo-A and its receptor are few

the mechanisms are unknown.Therefore discussing the potential value of drug development and targets of Nogo-A and NgR is necessary. This review is providing a reference to TCM used in clinical treatment of diseases that are bound up with targets of Nogo-A and NgR

and new drug research and development of TCM that promote nerve regeneration in the future.