檀香不同提取部位对小肠推进和胃排空的影响

郭建生; 刘红艳; 王小娟; 张猛; 陈君; 聂子文

doi:CNKI:11-3495/R.20111116.1422.001

您当前的位置：

首页 >

文章列表页 >

檀香不同提取部位对小肠推进和胃排空的影响

更新时间：2024-01-04

- 檀香不同提取部位对小肠推进和胃排空的影响
- Effect of the Different Extracts of Santali Albi Lignum on Isolated the Small Intestine Movement Function and Gastric Emptying of Mice
- 中国实验方剂学杂志 2012年18卷第2期页码：139-143
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家科技部"973"项目(2007CB512603);国家重点基础研究发展计划项目(2007CB512600);湖南省科技计划项目(2007WK3033);湖南省中药重点学科
- DOI：CNKI:11-3495/R.20111116.1422.001
  中图分类号：
- 纸质出版日期：2012
- 稿件说明：
移动端阅览
郭建生, 刘红艳, 王小娟, 等. 檀香不同提取部位对小肠推进和胃排空的影响[J]. 中国实验方剂学杂志, 2012,18(2):139-143.

GUO Jian-sheng, LIU Hong-yan, HUANG Xiao-juan, et al. Effect of the Different Extracts of Santali Albi Lignum on Isolated the Small Intestine Movement Function and Gastric Emptying of Mice[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(2): 139-143.
郭建生, 刘红艳, 王小娟, 等. 檀香不同提取部位对小肠推进和胃排空的影响[J]. 中国实验方剂学杂志, 2012,18(2):139-143. DOI： CNKI:11-3495/R.20111116.1422.001.

GUO Jian-sheng, LIU Hong-yan, HUANG Xiao-juan, et al. Effect of the Different Extracts of Santali Albi Lignum on Isolated the Small Intestine Movement Function and Gastric Emptying of Mice[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(2): 139-143. DOI： CNKI:11-3495/R.20111116.1422.001.

摘要

目的: 观察檀香不同提取物对小肠推进和胃排空的影响

探讨其作用机制。方法: 小鼠随即分为空白对照组

各提取部位组。各给药组ig相应药物

给药剂量按生药量计为1.9 g·kg-1

空白对照组ig等体积蒸馏水。每日1次

连续ig 3 d。采用酚红排空法

以正常、新斯的明、阿托品负荷为实验模型

观察檀香不同提取物对小鼠小肠推进和胃排空的影响。结果: 檀香水提液、醇提液、挥发油、水提液乙醚萃取部位对正常小鼠胃排空有抑制作用(P<0.05)

表现为胃残留率增大。檀香水煎液、醇提液、水提液乙醚萃取部位阿托品造成的小鼠胃排空抑制模型有拮抗作用(P<0.05)

表现为残留率减小

檀香水煎液对阿托品造成的小鼠小肠推进抑制模型有拮抗作用(P<0.05)

表现为推进率增大。檀香水煎液、醇提液、挥发油、醇提液乙酸乙酯萃取部位对新斯的明造成的小鼠胃排空亢进模型有拮抗作用(P<0.05)

表现为残留率增大

檀香水煎液、醇提液、挥发油、水提液乙醚萃取部位、醇提液乙醚萃取部位、醇提液乙酸乙酯萃取部位对新斯的明造成的小鼠小肠推进亢进模型有拮抗作用(P<0.05)

表现为推进率减小。檀香水提液部位、醇提液部位、挥发油部位和醇提液乙醚部位对新斯的明造成的小鼠胃排空亢进模型有拮抗作用(P<0.05)

表现为排空率增大。结论: 檀香对小鼠小肠推进和胃排空有双向调节作用

檀香水煎液、醇提液对阿托品造成的肠松弛模型及新斯的明造成的肠痉挛模型均有明显的拮抗作用

檀香挥发油在新斯的明造成的肠痉挛模型中表现出明显的拮抗作用

故可认为檀香水煎液、醇提液、挥发油是檀香"行气"作用的有效部位。

Abstract

Objective: To observe effects and mechanism of the Santali Albi Lignum different extracts on small intestine propulsion and gastric emptying. Method: Mice were randomly divided into control group and groups of extracted parts. The treatment groups take corresponding exreacts with dose of 1.9 g·kg-1

once a day for 3 days. Phenol red emptying method was used

normal

neostigmine and atropine load mice were used for experimental models. Result: Santali Albi Lignum water liquid

ethanol-extraction liquid

naphtha

water liquid ether extract part of the gastric inhibited emptying normal mice (P<0.05)

the stomach and retention rate increased. Santali Albi Lignum water fluid

liquid water extract-alcohol ethanol-extraction

liquid ether extract part inhibited emptying in atropine gastric inhibition models (P<0.05)

the residual rate decreased

and Santali Albi Lignum water decoction inhibited small intestine movement in atropine mice models (P<0.05)

promoting rate increased. The decoction of Santali Albi Lignum

ethanol-extraction liquid

naphtha

ethanol-extraction liquid ethyl acetate extract inhibited gastric emptying in neostigmine induced mice model (P<0.05)。The performance for the retention rate increased

the decoction of Santali Albi Lignum

ethanol-extraction liquid

naphtha

water liquid ether extract parts and ethanol-extraction liquid ether extract parts and ethanol-extraction liquid ethyl acetate extract inhibited small intestine propulsion in model mice induced by neostigmine (P<0.05)

promoting rate reduced. Santali Albi Lignum water liquid part

ethanol-extraction liquid part

naphtha parts and ethanol-extraction liquid petroleum ether parts and ethanol-extraction liquid ether inhibited mice induced gastric emptying in model mice induced by neostigmine (P<0.05)

emptying rate increased. Conclusion: Santali Albi Lignum on small intestine propulsion and gastric emptying have two-wayregulation function

Santali Albi Lignum water fluid

ethanol-extraction liquid in atropine and neostigmine models have significantl inhibition Santali Albi Lignum

and volatile model experiments showed obvious inhibitory effect on intestines convulsion

therefoer decoction of ethanol-extraction

liquid

naphtha is the effective parts.

关键词

Keywords

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

枳壳化学拆分组分的性味药理学评价——化学拆分组分的制备及其对胃肠功能作用的影响

加味香砂六君子汤辨治糖尿病胃轻瘫脾胃虚弱证的临床疗效

生附片与不同品种贝母配伍的药效学比较研究

白术挥发油对小鼠胃肠功能的影响