Objective: To observe the effect of Qiyuan cream flavored(QYCF) on blood glucose and blood lipids in the diabetic rats with type 2 diabetes. Method: Ten of 70 Wistar male rats were selected as normal group

other rats were used to establish type 2 diabetic model by the injection of streptozotocin(STZ) of 35 mg·kg-1through intraperitoneal with high sugar and high fat for 7 days. Then

the rats were divided into model group treated with normal saline

0.5 g·kg-1metformin hydrochloride group

2.5 g·kg-1 dosage of QYCF

5 g·kg-1 dosage group of QYCF and 10 g·kg-1 dosage group QYCF. After 3 weeks of administration level of blood glucose and lipids was observed. Result: Compared with fasting blood glucose(FBG) level in model group (22.00±1.30)mmol·L-1

FBG level in low

medium and high dose QYCF group was(16.00±1.22)

(14.63±1.30)

(13.25±1.28) mmol·L-1

respectively(P<0.05).Compared with serum insulin level of model group (11.86±0.79) μg·L-1

serum insulin level of QYCF groups was (16.17±0.99)

(18.11±0.75)

(19.07±0.77) μg·L-1

respectively(P<0.05). All the three QYCF groups could reduce the serum total cholesterol

triglyceride concentration and low density lipoprotein(P<0.05)

raising high density lipoprotein(P<0.05) in rats. Conclusion: QYCF has the effects of reducing blood glucose

improving blood lipids and raising serum insulin.