“The Kaixuan Detoxification Core Formula has an improving effect on the psoriasis like lesions induced by the combination of imiquimod and restraint stress in mice. This study explores the mechanism of traditional Chinese medicine compound in treating stress-induced severe silver chip disease by regulating HPA axis function, inhibiting central nervous system histopathological changes, and alleviating skin neuritis, laying the foundation for the construction of a combined traditional Chinese and Western medicine prevention and treatment system for psoriasis.”