“The Kaixuan Detoxification Core Formula may improve psoriasis like lesions by downregulating the overexpressed cold sensitive receptor TRPM8 in skin lesions, correcting its mediated neuropeptide release disorder, thereby inhibiting the activation of inflammatory pathways, regulating the "Xuanfu TRPM8 neuroimmune" axis, and opening up new directions for the treatment of psoriasis in cold environments.”